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Bacillus subtilis Protects Porcine Intestinal Barrier from Deoxynivalenol via Improved Zonula Occludens-1 Expression

구민정 ; 송선광 ; 박성무 ; 이인규 ; 윤철희

ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 2014, 27(4), , pp.580-586 [Periódico revisado por pares]

Korea (South): 아세아·태평양축산학회

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  • Título:
    Bacillus subtilis Protects Porcine Intestinal Barrier from Deoxynivalenol via Improved Zonula Occludens-1 Expression
  • Autor: 구민정 ; 송선광 ; 박성무 ; 이인규 ; 윤철희
  • Assuntos: Bacillus subtilis ; Cell junctions ; Cell research ; Epithelial cells ; Gene expression ; Genetic aspects ; Genetic research ; Health aspects ; Intestines ; Junctional complexes (Epithelium) ; 축산학
  • É parte de: ASIAN-AUSTRALASIAN JOURNAL OF ANIMAL SCIENCES, 2014, 27(4), , pp.580-586
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    KISTI1.1003/JNL.JAKO201409150680579
    Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 151-742, Korea
    These two authors contribute equally to this work.
    http://www.ajas.info/Editor/manuscript/upload/AJAS_Apr2014_27_580.pdf
    G704-001112.2014.27.4.002
  • Descrição: Intestinal epithelial cells (IECs) forming the barrier for the first-line of protection are interconnected by tight junction (TJ) proteins. TJ alteration results in impaired barrier function, which causes potentially excessive inflammation leading to intestinal disorders. It has been suggested that toll-like receptor (TLR) 2 ligands and some bacteria enhance epithelial barrier function in humans and mice. However, no such study has yet to be claimed in swine. The aim of the present study was to examine whether Bacillus subtilis could improve barrier integrity and protection against deoxynivalenol (DON)-induced barrier disruption in porcine intestinal epithelial cell line (IPEC-J2). We found that B. subtilis decreased permeability of TJ and improved the expression of zonula occludens (ZO)-1 and occludin during the process of forming TJ. In addition, ZO-1 expression of IPEC-J2 cells treated with B. subtilis was up-regulated against DON-induced damage. In conclusion, B. subtilis may have potential to enhance epithelial barrier function and to prevent the cells from DON-induced barrier dysfunction.
  • Editor: Korea (South): 아세아·태평양축산학회
  • Idioma: Coreano;Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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