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Loss of hippocampal neurons after kainate treatment correlates with behavioral deficits

Maia, Gisela H ; Quesado, José L ; Soares, Joana I ; do Carmo, Joana M ; Andrade, Pedro A ; Andrade, José P ; Lukoyanov, Nikolai V de la Prida, Liset Menendez

PloS one, 2014-01, Vol.9 (1), p.e84722 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Loss of hippocampal neurons after kainate treatment correlates with behavioral deficits
Autor: Maia, Gisela H ; Quesado, José L ; Soares, Joana I ; do Carmo, Joana M ; Andrade, Pedro A ; Andrade, José P ; Lukoyanov, Nikolai V
de la Prida, Liset Menendez
Assuntos: Acids ; Analysis ; Anatomy ; Animal behavior ; Animals ; Anxiety ; Avoidance ; Avoidance Learning - drug effects ; Behavior, Animal - drug effects ; Biology ; Brain ; Brain architecture ; Correlation analysis ; Epilepsy ; Fear conditioning ; Hippocampus ; Hippocampus - drug effects ; Hippocampus - pathology ; Hippocampus - physiopathology ; Kainic acid ; Kainic Acid - adverse effects ; Laboratory animals ; Male ; Maze Learning - drug effects ; Medicine ; Memory ; Memory - drug effects ; Memory tasks ; Nerve Degeneration ; Neurons ; Neurosciences ; Pyramidal Cells - drug effects ; Pyramidal Cells - pathology ; Rats ; Rodents ; Seizures ; Seizures (Medicine) ; Spatial analysis ; Spatial memory ; Structure-function relationships
É parte de: PloS one, 2014-01, Vol.9 (1), p.e84722
Notas: Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: GHM NVL. Performed the experiments: GHM JIS JMC. Analyzed the data: GHM JLQ PAA JAP NVL. Contributed reagents/materials/analysis tools: JPA NVL. Wrote the paper: GHM NVL.
Descrição: Treating rats with kainic acid induces status epilepticus (SE) and leads to the development of behavioral deficits and spontaneous recurrent seizures later in life. However, in a subset of rats, kainic acid treatment does not induce overt behaviorally obvious acute SE. The goal of this study was to compare the neuroanatomical and behavioral changes induced by kainate in rats that developed convulsive SE to those who did not. Adult male Wistar rats were treated with kainic acid and tested behaviorally 5 months later. Rats that had experienced convulsive SE showed impaired performance on the spatial water maze and passive avoidance tasks, and on the context and tone retention tests following fear conditioning. In addition, they exhibited less anxiety-like behaviors than controls on the open-field and elevated plus-maze tests. Histologically, convulsive SE was associated with marked neuron loss in the hippocampal CA3 and CA1 fields, and in the dentate hilus. Rats that had not experienced convulsive SE after kainate treatment showed less severe, but significant impairments on the spatial water maze and passive avoidance tasks. These rats had fewer neurons than control rats in the dentate hilus, but not in the hippocampal CA3 and CA1 fields. Correlational analyses revealed significant relationships between spatial memory indices of rats and neuronal numbers in the dentate hilus and CA3 pyramidal field. These results show that a part of the animals that do not display intense behavioral seizures (convulsive SE) immediately after an epileptogenic treatment, later in life, they may still have noticeable structural and functional changes in the brain.
Editor: United States: Public Library of Science
Idioma: Inglês

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Loss of hippocampal neurons after kainate treatment correlates with behavioral deficits

Maia, Gisela H ; Quesado, José L ; Soares, Joana I ; do Carmo, Joana M ; Andrade, Pedro A ; Andrade, José P ; Lukoyanov, Nikolai V de la Prida, Liset Menendez

United States: Public Library of Science

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