Idioma:

A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent

Cantalupo Lima, Camila Barbara (Universidade Estadual de Campinas, Campinas, SP, Brazil) ; Arrais-Silva, Wagner Welber (Universidade Estadual de Campinas, Campinas, SP, Brazil) ; Rodrigues Cunha, Rodrigo Luiz Oliveira (Universidade de Sao Paulo, Sao Paulo, SP, Brazil) ; Giorgio, Selma (Universidade de Sao Paulo, Sao Paulo, SP, Brazil), E-mail: sgiorgio@unicamp.br

Korean journal of parasitology, 2009-09, Vol.47 (3), p.213-218

Korea (South): 대한기생충학열대의학회

Texto completo disponível

Citações Citado por

Enviar para

Título:
A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent
Autor: Cantalupo Lima, Camila Barbara (Universidade Estadual de Campinas, Campinas, SP, Brazil) ; Arrais-Silva, Wagner Welber (Universidade Estadual de Campinas, Campinas, SP, Brazil) ; Rodrigues Cunha, Rodrigo Luiz Oliveira (Universidade de Sao Paulo, Sao Paulo, SP, Brazil) ; Giorgio, Selma (Universidade de Sao Paulo, Sao Paulo, SP, Brazil), E-mail: sgiorgio@unicamp.br
Assuntos: Animals ; antileishmanial drug ; Antiprotozoal Agents - pharmacology ; Disease Models, Animal ; DRUG THERAPY ; Female ; Humans ; Leishmania amazonensis ; Leishmania mexicana - drug effects ; LEISHMANIASIS ; Leishmaniasis - drug therapy ; Leishmaniasis - parasitology ; LEISHMANIOSE ; Mice ; Mice, Inbred BALB C ; Organometallic Compounds - pharmacology ; organotellurium compound ; Original ; TERAPEUTICA MEDICAMENTOSA ; THERAPEUTIQUE MEDICAMENTEUSE
É parte de: Korean journal of parasitology, 2009-09, Vol.47 (3), p.213-218
Notas: L72
2009003934
Descrição: Leishmaniasis is a neglected disease and endemic in developing countries. A lack of adequate and definitive chemotherapeutic agents to fight against this infection has led to the investigation of numerous compounds. The aim of this study was to investigate the effect of RT-01, an organotellurane compound presenting biological activities, in 2 experimental systems against Leishmania amazonensis. The in vitro system consisted of promastigotes and amastigotes forms of the parasite, and the in vivo system consisted of L. amazonensis infected BALB/c mice, an extremely susceptible mouse strain. The compound proved to be toxic against promastigotes and amastigotes. The study also showed that treatment with RT-01 produces an effect similar to that treatment with the reference antimonial drug, Glucantime, in L. amazonensis infected mice. The best results were obtained following RT-01 intralesional administration (720 ㎍/kg/day); mice showed significant delay in the development of cutaneous lesions and decreased numbers of parasites obtained from the lesions. Significant differences in tissue pathology consisted mainly of no expressive accumulation of inflammatory cells and well-preserved structures in the skin tissue of RT-01-treated mice compared with expressive infiltration of infected cells replacing the skin tissue in lesions of untreated mice. These findings highlight the fact that the apparent potency of organotellurane compounds, together with their relatively simple structure, may represent a new avenue for the development of novel drugs to combat parasitic diseases.
Editor: Korea (South): 대한기생충학열대의학회
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent

Korea (South): 대한기생충학열대의학회

Buscando em bases de dados remotas. Favor aguardar.