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Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: Relation to angiographic coronary artery disease

de Souza, Ana Carolina do A.H. ; Gonçalves, Bernardo K.D. ; Tedeschi, Angelo L. ; Lima, Ronaldo S.L.

Journal of nuclear cardiology, 2021-06, Vol.28 (3), p.876-884 [Periódico revisado por pares]

Cham: Elsevier Inc

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Título:
Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: Relation to angiographic coronary artery disease
Autor: de Souza, Ana Carolina do A.H. ; Gonçalves, Bernardo K.D. ; Tedeschi, Angelo L. ; Lima, Ronaldo S.L.
Assuntos: Aged ; Algorithms ; Angiography ; Animals ; CAD ; Cadmium ; Cameras ; Cardiology ; Cardiovascular disease ; Coronary Angiography - methods ; Coronary Artery Disease - diagnostic imaging ; Female ; Fractional Flow Reserve, Myocardial ; Gamma Cameras ; Humans ; Image Processing, Computer-Assisted ; Imaging ; Male ; Medical imaging ; Medicine ; Medicine & Public Health ; Middle Aged ; MPI ; myocardial blood flow ; Myocardial Perfusion Imaging - methods ; Nuclear Medicine ; Original Article ; Perfusion ; Prospective Studies ; Radiology ; Reproducibility of Results ; Risk ; ROC Curve ; Sensitivity and Specificity ; SPECT ; Tellurium ; Tomography ; Zinc
É parte de: Journal of nuclear cardiology, 2021-06, Vol.28 (3), p.876-884
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Previous studies have suggested using gamma cameras with cadmium-zinc-telluride (CZT) detectors to quantify myocardial blood flow (MBF) and flow reserve (MFR). In this study, we aimed to evaluate the feasibility and accuracy of MFR quantification using a CZT camera compared to coronary angiography. Forty-one participants referred for coronary angiography underwent a rest/stress one-day myocardial perfusion imaging protocol using a CZT gamma camera. Rest and stress dynamic phases were followed by acquisition of traditional perfusion images and time-activity curves were generated. Angiographic and perfusion results were compared to MFR. Patients with abnormal perfusion presented reduced MFR (2.01 [1.48-2.77] vs. 2.94 [2.38-3.64], P = 0.002), and reduced stress MBF. Patients with high-risk CAD had lower global MFR compared to patients without obstructive disease (1.99 [1.22-2.84] vs. 2.89 [2.22-3.58], P = 0.026). Obstructed vessels showed lower regional MFR when compared to non-obstructed (1.81 [1.19-2.67] vs. 2.75 [2.13-3.42], P < 0.001). A regional MFR of 2.2 provided a sensitivity of 63.2% and specificity of 74.1% to identify an obstructive lesion in the corresponding artery. In patients undergoing invasive coronary angiography for the evaluation of CAD, quantifying MBF and MFR in a CZT gamma camera is feasible and reflects underlying disease. In these patients, reduced regional MFR suggests the presence of obstructive lesion(s).
Editor: Cham: Elsevier Inc
Idioma: Inglês

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Quantification of myocardial flow reserve using a gamma camera with solid-state cadmium-zinc-telluride detectors: Relation to angiographic coronary artery disease

de Souza, Ana Carolina do A.H. ; Gonçalves, Bernardo K.D. ; Tedeschi, Angelo L. ; Lima, Ronaldo S.L.

Cham: Elsevier Inc

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