Idioma:

Characterization of women with elevated antimüllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes

Tal, Reshef, MD, PhD ; Seifer, David B., MD ; Khanimov, Moisey, BA ; Malter, Henry E., PhD ; Grazi, Richard V., MD ; Leader, Ben, MD, PhD

American journal of obstetrics and gynecology, 2014-07, Vol.211 (1), p.59.e1-59.e8 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Characterization of women with elevated antimüllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes
Autor: Tal, Reshef, MD, PhD ; Seifer, David B., MD ; Khanimov, Moisey, BA ; Malter, Henry E., PhD ; Grazi, Richard V., MD ; Leader, Ben, MD, PhD
Assuntos: Adult ; Amenorrhea - blood ; Amenorrhea - etiology ; Anti-Mullerian Hormone - blood ; antimüllerian hormone (AMH) ; assisted reproductive technology (ART) ; Biomarkers - blood ; Cohort Studies ; Female ; Humans ; Infertility, Female - etiology ; Infertility, Female - therapy ; Obstetrics and Gynecology ; outcomes ; Ovulation Induction ; Phenotype ; polycystic ovarian syndrome (PCOS) ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - diagnosis ; Pregnancy ; Pregnancy Rate ; Retrospective Studies ; ROC Curve ; Severity of Illness Index ; Treatment Outcome ; ultrahigh AMH
É parte de: American journal of obstetrics and gynecology, 2014-07, Vol.211 (1), p.59.e1-59.e8
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
Descrição: Objective Serum Antimüllerian hormone (AMH) levels are elevated in polycystic ovarian syndrome and have been shown to be useful in its diagnosis. However, the clinical significance of extremely high AMH levels is understudied. We aimed to characterize a population of women with elevated AMH (>5 ng/mL). Study Design This was a retrospective cohort study of 134 women presenting to our fertility clinic for infertility evaluation and treatment who were found to have random serum AMH over 5 ng/mL. Women were divided into 3 groups according to AMH: 5-10 ng/mL, >10-14 ng/mL, and >14 ng/mL. Endocrine characteristics, polycystic ovarian syndrome (PCOS) phenotypes, fertilization rate, implantation rate, clinical pregnancy, and multiple pregnancy rates were compared between groups. Results AMH ranged between 5 to 48 ng/mL. Greater than 97% of women with ultrahigh AMH (>10 ng/mL) had PCOS. In addition, women with AMH >10 ng/mL had greater prevalence of polycystic ovarian morphology and oligoamenorrhea than women with AMH 5-10 ng/mL. Moreover, serum AMH correlated positively with luteinizing hormone, total testosterone, and dehydroepiandrosterone sulfate. Furthermore, AMH showed strong predictive ability for the presence of amenorrhea (area under the curve, 0.87; 95% confidence interval, 0.80–0.92; P < .0001). Despite similar age and mean number of transferred embryos, women with AMH >10 ng/mL showed higher rates of ovarian hyperstimulation syndrome and clinical pregnancy rates compared with women with AMH 5-10 ng/mL. Conclusion These data characterize a population of women with elevated AMH levels, demonstrating that the vast majority of women with AMH >10 ng/mL have PCOS. Increased AMH levels correlated with PCOS severity and are associated with greater ovarian stimulation and higher clinical pregnancy rates following assisted reproductive technology.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Characterization of women with elevated antimüllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes

Tal, Reshef, MD, PhD ; Seifer, David B., MD ; Khanimov, Moisey, BA ; Malter, Henry E., PhD ; Grazi, Richard V., MD ; Leader, Ben, MD, PhD

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.