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Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study

Meidtner, Karina ; Podmore, Clara ; Kröger, Janine ; van der Schouw, Yvonne T ; Bendinelli, Benedetta ; Agnoli, Claudia ; Arriola, Larraitz ; Barricarte, Aurelio ; Boeing, Heiner ; Cross, Amanda J ; Dow, Courtney ; Ekblom, Kim ; Fagherazzi, Guy ; Franks, Paul W ; Gunter, Marc J ; Huerta, José María ; Jakszyn, Paula ; Jenab, Mazda ; Katzke, Verena A ; Key, Timothy J ; Khaw, Kay Tee ; Kühn, Tilman ; Kyrø, Cecilie ; Mancini, Francesca Romana ; Melander, Olle ; Nilsson, Peter M ; Overvad, Kim ; Palli, Domenico ; Panico, Salvatore ; Quirós, J Ramón ; Rodríguez-Barranco, Miguel ; Sacerdote, Carlotta ; Sluijs, Ivonne ; Stepien, Magdalena ; Tjonneland, Anne ; Tumino, Rosario ; Forouhi, Nita G ; Sharp, Stephen J ; Langenberg, Claudia ; Schulze, Matthias B ; Riboli, Elio ; Wareham, Nicholas J

Diabetes care, 2018-02, Vol.41 (2), p.277-285 [Periódico revisado por pares]

United States: American Diabetes Association

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Título:
Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study
Autor: Meidtner, Karina ; Podmore, Clara ; Kröger, Janine ; van der Schouw, Yvonne T ; Bendinelli, Benedetta ; Agnoli, Claudia ; Arriola, Larraitz ; Barricarte, Aurelio ; Boeing, Heiner ; Cross, Amanda J ; Dow, Courtney ; Ekblom, Kim ; Fagherazzi, Guy ; Franks, Paul W ; Gunter, Marc J ; Huerta, José María ; Jakszyn, Paula ; Jenab, Mazda ; Katzke, Verena A ; Key, Timothy J ; Khaw, Kay Tee ; Kühn, Tilman ; Kyrø, Cecilie ; Mancini, Francesca Romana ; Melander, Olle ; Nilsson, Peter M ; Overvad, Kim ; Palli, Domenico ; Panico, Salvatore ; Quirós, J Ramón ; Rodríguez-Barranco, Miguel ; Sacerdote, Carlotta ; Sluijs, Ivonne ; Stepien, Magdalena ; Tjonneland, Anne ; Tumino, Rosario ; Forouhi, Nita G ; Sharp, Stephen J ; Langenberg, Claudia ; Schulze, Matthias B ; Riboli, Elio ; Wareham, Nicholas J
Assuntos: Biomarkers ; Clinical Medicine ; Cohort Studies ; Cross-Sectional Studies ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - metabolism ; Diet ; Endocrinology and Diabetes ; Endokrinologi och diabetes ; Europe - epidemiology ; Female ; Ferritin ; Ferritins - genetics ; Gene-Environment Interaction ; Genetic factors ; Genetics ; Genome-Wide Association Study ; Genomes ; Hazards ; Health risks ; Heme ; Hemochromatosis Protein - genetics ; Humans ; Iron ; Iron - metabolism ; Klinisk medicin ; Male ; Meat ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Polymorphism, Single Nucleotide ; Population studies ; Research design ; Risk ; Risk Factors ; Single-nucleotide polymorphism ; Transferrin ; Transferrin - genetics
É parte de: Diabetes care, 2018-02, Vol.41 (2), p.277-285
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Meat intake has been consistently shown to be positively associated with incident type 2 diabetes. Part of that association may be mediated by body iron status, which is influenced by genetic factors. We aimed to test for interactions of genetic and dietary factors influencing body iron status in relation to the risk of incident type 2 diabetes. The case-cohort comprised 9,347 case subjects and 12,301 subcohort participants from eight European countries. Single nucleotide polymorphisms (SNPs) were selected from genome-wide association studies on iron status biomarkers and candidate gene studies. A ferritin-related gene score was constructed. Multiplicative and additive interactions of heme iron and SNPs as well as the gene score were evaluated using Cox proportional hazards regression. Higher heme iron intake (per 1 SD) was associated with higher ferritin levels (β = 0.113 [95% CI 0.082; 0.144]), but not with transferrin (-0.019 [-0.043; 0.006]) or transferrin saturation (0.016 [-0.006; 0.037]). Five SNPs located in four genes (rs1799945 [ H63D], rs1800562 [ C282Y], rs236918 [ ], rs744653 [ ], and rs855791 [ V736A]) were associated with ferritin. We did not detect an interaction of heme iron and the gene score on the risk of diabetes in the overall study population ( = 0.16, = 0.21) but did detect a trend toward a negative interaction in men ( = 0.04, = 0.03). We found no convincing evidence that the interplay of dietary and genetic factors related to body iron status associates with type 2 diabetes risk above the level expected from the sum or product of the two individual exposures.
Editor: United States: American Diabetes Association
Idioma: Inglês

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Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study

United States: American Diabetes Association

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