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Application of failure mode and effects analysis to treatment planning in scanned proton beam radiotherapy

Cantone, Marie Claire ; Ciocca, Mario ; Dionisi, Francesco ; Fossati, Piero ; Lorentini, Stefano ; Krengli, Marco ; Molinelli, Silvia ; Orecchia, Roberto ; Schwarz, Marco ; Veronese, Ivan ; Vitolo, Viviana

Radiation oncology (London, England), 2013-05, Vol.8 (1), p.127-127, Article 127 [Periódico revisado por pares]

England: BioMed Central Ltd

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  • Título:
    Application of failure mode and effects analysis to treatment planning in scanned proton beam radiotherapy
  • Autor: Cantone, Marie Claire ; Ciocca, Mario ; Dionisi, Francesco ; Fossati, Piero ; Lorentini, Stefano ; Krengli, Marco ; Molinelli, Silvia ; Orecchia, Roberto ; Schwarz, Marco ; Veronese, Ivan ; Vitolo, Viviana
  • Assuntos: Clinical medicine ; CT imaging ; Diagnostic imaging ; Drug dosages ; Failure analysis ; Failure mode and effects analysis ; Humans ; Industrial safety ; Methods ; Oncology ; Patient safety ; Proton beam radiotherapy ; Proton Therapy - methods ; Quality control ; Radiation Injuries - prevention & control ; Radiation therapy ; Radiotherapy Planning, Computer-Assisted - methods ; Risk Assessment ; Risk Management - methods ; Studies
  • É parte de: Radiation oncology (London, England), 2013-05, Vol.8 (1), p.127-127, Article 127
  • Descrição: A multidisciplinary and multi-institutional working group applied the Failure Mode and Effects Analysis (FMEA) approach to the actively scanned proton beam radiotherapy process implemented at CNAO (Centro Nazionale di Adroterapia Oncologica), aiming at preventing accidental exposures to the patient. FMEA was applied to the treatment planning stage and consisted of three steps: i) identification of the involved sub-processes; ii) identification and ranking of the potential failure modes, together with their causes and effects, using the risk probability number (RPN) scoring system, iii) identification of additional safety measures to be proposed for process quality and safety improvement. RPN upper threshold for little concern of risk was set at 125. Thirty-four sub-processes were identified, twenty-two of them were judged to be potentially prone to one or more failure modes. A total of forty-four failure modes were recognized, 52% of them characterized by an RPN score equal to 80 or higher. The threshold of 125 for RPN was exceeded in five cases only. The most critical sub-process appeared related to the delineation and correction of artefacts in planning CT data. Failures associated to that sub-process were inaccurate delineation of the artefacts and incorrect proton stopping power assignment to body regions. Other significant failure modes consisted of an outdated representation of the patient anatomy, an improper selection of beam direction and of the physical beam model or dose calculation grid. The main effects of these failures were represented by wrong dose distribution (i.e. deviating from the planned one) delivered to the patient. Additional strategies for risk mitigation, easily and immediately applicable, consisted of a systematic information collection about any known implanted prosthesis directly from each patient and enforcing a short interval time between CT scan and treatment start. Moreover, (i) the investigation of dedicated CT image reconstruction algorithms, (ii) further evaluation of treatment plan robustness and (iii) implementation of independent methods for dose calculation (such as Monte Carlo simulations) may represent novel solutions to increase patient safety. FMEA is a useful tool for prospective evaluation of patient safety in proton beam radiotherapy. The application of this method to the treatment planning stage lead to identify strategies for risk mitigation in addition to the safety measures already adopted in clinical practice.
  • Editor: England: BioMed Central Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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