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Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil

Oliveira-Filho, Edmilson Ferreira de ; Dos Santos, Debora Rl ; Durães-Carvalho, Ricardo ; da Silva, Adalúcia ; de Lima, Gustavo Barbosa ; Batista Filho, Antônio Fernando B ; Pena, Lindomar J ; Gil, Laura Hvg

Memórias do Instituto Oswaldo Cruz, 2019-01, Vol.114, p.e180585-e180585 [Periódico revisado por pares]

Brazil: Instituto Oswaldo Cruz, Ministério da Saúde

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  • Título:
    Evolutionary study of potentially zoonotic hepatitis E virus genotype 3 from swine in Northeast Brazil
  • Autor: Oliveira-Filho, Edmilson Ferreira de ; Dos Santos, Debora Rl ; Durães-Carvalho, Ricardo ; da Silva, Adalúcia ; de Lima, Gustavo Barbosa ; Batista Filho, Antônio Fernando B ; Pena, Lindomar J ; Gil, Laura Hvg
  • Assuntos: genotype 3 ; PARASITOLOGY ; Short Communication ; swine ; TROPICAL MEDICINE ; zoonotic hepatitis E virus
  • É parte de: Memórias do Instituto Oswaldo Cruz, 2019-01, Vol.114, p.e180585-e180585
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    EFOF - Study conception and design, acquisition of data, analysis and interpretation of data, drafting of manuscript, critical revision; DRLS and RD-C - analysis and interpretation of data, drafting of manuscript, critical revision; AS, GBL, AFBBF and LJP - study conception and design, acquisition of data, critical revision; LHVGG - study conception and design, analysis and interpretation of data, drafting of manuscript, critical revision.
  • Descrição: Hepatitis E virus (HEV), an emerging virus associated with acute hepatic disease, leads to thousands of deaths worldwide. HEV has already been reported in Brazil; however, there is a lack of epidemiological and molecular information on the genetic variability, taxonomy, and evolution of HEV. It is thus unclear whether hepatitis E is a neglected disease in Brazil or it has low relevance for public health in this country. Here, for the first time, we report the presence of HEV in Northeast Brazil. A total of 119 swine faecal samples were screened for the presence of HEV RNA using real-time polymerase chain reaction (RT-PCR) and further confirmed by conventional RT-PCR; among these, two samples were identified as positive. Molecular evolution analyses based on capsid sequences revealed that the samples had close proximities to HEV sequences belonging to genotype 3 and were genetically related to subtype 3f isolated in humans. Parsimony ancestral states analysis indicated gene flow events from HEV cross-species infection, suggesting an important role of pig hosts in viral spillover. HEV's ability for zoonotic transmission by inter-species host switching as well as its possible adaptation to new animal species remain important issues for human health.
  • Editor: Brazil: Instituto Oswaldo Cruz, Ministério da Saúde
  • Idioma: Inglês;Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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