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Architecture of the Mouse Brain Synaptome

Zhu, Fei ; Cizeron, Mélissa ; Qiu, Zhen ; Benavides-Piccione, Ruth ; Kopanitsa, Maksym V. ; Skene, Nathan G. ; Koniaris, Babis ; DeFelipe, Javier ; Fransén, Erik ; Komiyama, Noboru H. ; Grant, Seth G.N.

Neuron (Cambridge, Mass.), 2018-08, Vol.99 (4), p.781-799.e10 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Architecture of the Mouse Brain Synaptome
Autor: Zhu, Fei ; Cizeron, Mélissa ; Qiu, Zhen ; Benavides-Piccione, Ruth ; Kopanitsa, Maksym V. ; Skene, Nathan G. ; Koniaris, Babis ; DeFelipe, Javier ; Fransén, Erik ; Komiyama, Noboru H. ; Grant, Seth G.N.
Assuntos: Animals ; Brain - diagnostic imaging ; Brain - physiology ; Brain architecture ; Brain Chemistry - physiology ; Cognitive ability ; Computational Biology - methods ; connectome ; Connectome - methods ; Gene mapping ; Genes ; machine learning ; Male ; Medicin och hälsovetenskap ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microscopy ; Morphology ; Mutation ; Neuroimaging ; Proteins ; Proteome - analysis ; Proteome - physiology ; PSD95 ; Rodents ; SAP102 ; Spatial distribution ; Structure-function relationships ; synapse diversity ; synapse proteome ; Synapses - chemistry ; Synapses - physiology ; synaptic proteins ; synaptome ; synaptomic
É parte de: Neuron (Cambridge, Mass.), 2018-08, Vol.99 (4), p.781-799.e10
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
USDOE EM Office of Technology Innovation and Development (EM-30)
202932; HEALTH-F2-2009-241498; 720270; 695568; CB06/05/0066
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These authors contributed equally
Descrição: Synapses are found in vast numbers in the brain and contain complex proteomes. We developed genetic labeling and imaging methods to examine synaptic proteins in individual excitatory synapses across all regions of the mouse brain. Synapse catalogs were generated from the molecular and morphological features of a billion synapses. Each synapse subtype showed a unique anatomical distribution, and each brain region showed a distinct signature of synapse subtypes. Whole-brain synaptome cartography revealed spatial architecture from dendritic to global systems levels and previously unknown anatomical features. Synaptome mapping of circuits showed correspondence between synapse diversity and structural and functional connectomes. Behaviorally relevant patterns of neuronal activity trigger spatiotemporal postsynaptic responses sensitive to the structure of synaptome maps. Areas controlling higher cognitive function contain the greatest synapse diversity, and mutations causing cognitive disorders reorganized synaptome maps. Synaptome technology and resources have wide-ranging application in studies of the normal and diseased brain. [Display omitted] •Single-synapse-resolution maps of postsynaptic proteins across the whole mouse brain•Systematic catalogs and anatomical mapping of synapse types and subtypes•Synapse diversity is organized into a synaptome map architecture•Disease-relevant mutations reprogram synaptome maps Synapse molecular composition and diversity was systematically mapped across the whole mouse brain. A molecular logic orchestrates the spatial architecture of synapse diversity from individual dendrites to the systems level. Synaptome architecture and function is important for cognition and disease.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Architecture of the Mouse Brain Synaptome

Zhu, Fei ; Cizeron, Mélissa ; Qiu, Zhen ; Benavides-Piccione, Ruth ; Kopanitsa, Maksym V. ; Skene, Nathan G. ; Koniaris, Babis ; DeFelipe, Javier ; Fransén, Erik ; Komiyama, Noboru H. ; Grant, Seth G.N.

United States: Elsevier Inc

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