skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast

Ojopi, Elida Paula Benquique ; Rogatto, Silvia Regina ; Caldeira, José Roberto Fígaro ; Barbiéri-Neto, Jose ; Squire, Jeremy A.

Genes chromosomes & cancer, 2001-01, Vol.30 (1), p.25-31 [Periódico revisado por pares]

New York: John Wiley & Sons, Inc

Texto completo disponível

Citações Citado por
  • Título:
    Comparative genomic hybridization detects novel amplifications in fibroadenomas of the breast
  • Autor: Ojopi, Elida Paula Benquique ; Rogatto, Silvia Regina ; Caldeira, José Roberto Fígaro ; Barbiéri-Neto, Jose ; Squire, Jeremy A.
  • Assuntos: Adolescent ; Adult ; Breast Neoplasms - genetics ; Chromosome Deletion ; Chromosome Mapping ; Female ; Fibroadenoma - genetics ; Gene Amplification ; Humans ; Middle Aged ; Nucleic Acid Hybridization
  • É parte de: Genes chromosomes & cancer, 2001-01, Vol.30 (1), p.25-31
  • Notas: ark:/67375/WNG-FTVN00GK-C
    Canadian Cancer Society; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); CNPq, São Paulo, Brazil
    Canadian Cancer Society
    istex:D60EE02993F999D74DB77454C24D901C26332C6D
    ArticleID:GCC1057
    National Cancer Institute of Canada
    ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Comparative genomic hybridization analysis was performed for identification of chromosomal imbalances in 23 samples of fibroadenomas of the breast. Chromosomal gains rather than losses were a feature of these lesions. Only two cases with a familial and/or previous history of breast lesions had gain of 1q or 16q as the sole abnormality. The most frequently overrepresented segments were 5p14 (10/23 cases), 5q34–qter (6/23 cases), 13q32–qter (6/23 cases), 10q25–qter (5/23 cases), and 18q22 (4/23 cases). Some of these regions have previously been associated with breast carcinoma, but this study indicates that gain of these regions can also occur in benign breast lesions. Our findings may provide a basis for conducting further investigations to locate and identify genes associated with proliferation that may be involved in the early steps of tumorigenesis of the breast. © 2000 Wiley‐Liss, Inc.
  • Editor: New York: John Wiley & Sons, Inc
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.