Idioma:

Fibrinogen as a major risk factor in cardiovascular disease

Cook, Nigel S. ; Ubben, David

Trends in Pharmacological Sciences, 1990-11, Vol.11 (11), p.444-451 [Periódico revisado por pares]

Texto completo disponível

Citações Citado por

Título:
Fibrinogen as a major risk factor in cardiovascular disease
Autor: Cook, Nigel S. ; Ubben, David
Assuntos: Animals ; Cardiovascular Diseases - etiology ; Fibrinogen - analysis ; Fibrinogen - physiology ; Humans ; Platelet Membrane Glycoproteins - analysis ; Platelet Membrane Glycoproteins - physiology ; Risk Factors
É parte de: Trends in Pharmacological Sciences, 1990-11, Vol.11 (11), p.444-451
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Evidence has accumulated over the past ten years to implicate elevated plasma fibrinogen levels in cardiovascular disorders such as ischaemic heart disease, stroke and peripheral vascular disease. At a cellular level, insight has been gained into the molecular regulation of fibrinogen biosynthesis and the mechanisms through which fibrinogen may be involved in these disease processes. Here, Nigel Cook and David Ubben summarize this evidence and consider the possibilities for novel therapies targeted at fibrinogen. A variety of structurally diverse pharmacological agents, many of which were developed for their effects on plasma lipids, have serendipitously been found to lower plasma fibrinogen levels.
Editor: England: Elsevier Ltd
Idioma: Inglês

Links

Voltar para lista de resultados