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Synergistic Manganese(I) C−H Activation Catalysis in Continuous Flow: Chemoselective Hydroarylation

Wang, Hui ; Pesciaioli, Fabio ; Oliveira, João C. A. ; Warratz, Svenja ; Ackermann, Lutz

Angewandte Chemie (International ed.), 2017-11, Vol.56 (47), p.15063-15067 [Periódico revisado por pares]

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Synergistic Manganese(I) C−H Activation Catalysis in Continuous Flow: Chemoselective Hydroarylation
Autor: Wang, Hui ; Pesciaioli, Fabio ; Oliveira, João C. A. ; Warratz, Svenja ; Ackermann, Lutz
Assuntos: Activation ; Alkynes ; Catalysis ; Continuous flow ; C−H activation ; flow chemistry ; heterocycles ; Manganese ; reaction mechanisms
É parte de: Angewandte Chemie (International ed.), 2017-11, Vol.56 (47), p.15063-15067
Notas: These authors contributed equally to this work.
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Descrição: Chemoselective hydroarylations were accomplished by a novel synergistic Brønsted acid/manganese(I)‐catalyzed C−H activation manifold. Thus, alkynes bearing O‐leaving groups could, for the first time, be employed for C−H alkenylations without concurrent β‐O elimination, thereby setting the stage for versatile late‐stage diversifications. Also described is the first manganese‐catalyzed C−H activation in continuous flow, thus enabling efficient hydroarylations within only 20 minutes. Mn with the flow: Synergistic Brønsted acid/manganese(I) catalysis enables chemoselective hydroarylations, in flow, within 1 to 20 minutes, and sets the stage for versatile late‐stage modifications. The reaction features facile C−H cleavage and the use of nontoxic sustainable manganese.
Editor: Germany: Wiley Subscription Services, Inc
Idioma: Inglês

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