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Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma

Cavo, Michele ; Pantani, Lucia ; Petrucci, Maria Teresa ; Patriarca, Francesca ; Zamagni, Elena ; Donnarumma, Daniela ; Crippa, Claudia ; Boccadoro, Mario ; Perrone, Giulia ; Falcone, Antonietta ; Nozzoli, Chiara ; Zambello, Renato ; Masini, Luciano ; Furlan, Anna ; Brioli, Annamaria ; Derudas, Daniele ; Ballanti, Stelvio ; Dessanti, Maria Laura ; De Stefano, Valerio ; Carella, Angelo Michele ; Marcatti, Magda ; Nozza, Andrea ; Ferrara, Felicetto ; Callea, Vincenzo ; Califano, Catello ; Pezzi, Annalisa ; Baraldi, Anna ; Grasso, Mariella ; Musto, Pellegrino ; Palumbo, Antonio

Blood, 2012-07, Vol.120 (1), p.9-19 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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Título:
Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma
Autor: Cavo, Michele ; Pantani, Lucia ; Petrucci, Maria Teresa ; Patriarca, Francesca ; Zamagni, Elena ; Donnarumma, Daniela ; Crippa, Claudia ; Boccadoro, Mario ; Perrone, Giulia ; Falcone, Antonietta ; Nozzoli, Chiara ; Zambello, Renato ; Masini, Luciano ; Furlan, Anna ; Brioli, Annamaria ; Derudas, Daniele ; Ballanti, Stelvio ; Dessanti, Maria Laura ; De Stefano, Valerio ; Carella, Angelo Michele ; Marcatti, Magda ; Nozza, Andrea ; Ferrara, Felicetto ; Callea, Vincenzo ; Califano, Catello ; Pezzi, Annalisa ; Baraldi, Anna ; Grasso, Mariella ; Musto, Pellegrino ; Palumbo, Antonio
Assuntos: Antineoplastic Agents - administration & dosage ; Antineoplastic Agents, Hormonal - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Biological and medical sciences ; Boronic Acids - administration & dosage ; Bortezomib ; Combined Modality Therapy ; Dexamethasone - administration & dosage ; Disease-Free Survival ; Female ; Hematologic and hematopoietic diseases ; Hematopoietic Stem Cell Transplantation - methods ; Humans ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulinopathies ; Immunopathology ; Immunosuppressive Agents - administration & dosage ; Kaplan-Meier Estimate ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Multiple Myeloma - diagnosis ; Multiple Myeloma - drug therapy ; Prognosis ; Pyrazines - administration & dosage ; Thalidomide - administration & dosage ; Transplantation, Autologous
É parte de: Blood, 2012-07, Vol.120 (1), p.9-19
Descrição: In a randomized, phase 3 study, superior complete/near-complete response (CR/nCR) rates and extended progression-free survival were demonstrated with bortezomib-thalidomide-dexamethasone (VTD) versus thalidomide-dexamethasone (TD) as induction therapy before, and consolidation after, double autologous stem cell transplantation for newly diagnosed myeloma patients (intention-to-treat analysis; VTD, n = 236; TD, n = 238). This per-protocol analysis (VTD, n = 160; TD, n = 161) specifically assessed the efficacy and safety of consolidation with VTD or TD. Before starting consolidation, CR/nCR rates were not significantly different in the VTD (63.1%) and TD arms (54.7%). After consolidation, CR (60.6% vs 46.6%) and CR/nCR (73.1% vs 60.9%) rates were significantly higher for VTD-treated versus TD-treated patients. VTD consolidation significantly increased CR and CR/nCR rates, but TD did not (McNemar test). With a median follow-up of 30.4 months from start of consolidation, 3-year progression-free survival was significantly longer for the VTD group (60% vs 48% for TD). Grade 2 or 3 peripheral neuropathy (8.1% vs 2.4%) was more frequent with VTD (grade 3, 0.6%) versus TD consolidation. The superior efficacy of VTD versus TD as induction was retained despite readministration as consolidation therapy after double autologous transplantation. VTD consolidation therapy significantly contributed to improved clinical outcomes observed for patients randomly assigned to the VTD arm of the study. The study is registered at www.clinicaltrials.gov as #NCT01134484.
Editor: Washington, DC: Elsevier Inc
Idioma: Inglês

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Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma

Washington, DC: Elsevier Inc

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