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Engraftment, clinical, and molecular follow-up of patients with multiple myeloma who were reinfused with highly purified CD34+ cells to support single or tandem high-dose chemotherapy

Lemoli, Roberto M. ; Martinelli, Giovanni ; Zamagni, Elena ; Motta, Maria Rosa ; Rizzi, Simonetta ; Terragna, Carolina ; Rondelli, Roberto ; Ronconi, Sonia ; Curti, Antonio ; Bonifazi, Francesca ; Tura, Sante ; Cavo, Michele

Blood, 2000-04, Vol.95 (7), p.2234-2239 [Periódico revisado por pares]

Washington, DC: Elsevier Inc

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Título:
Engraftment, clinical, and molecular follow-up of patients with multiple myeloma who were reinfused with highly purified CD34+ cells to support single or tandem high-dose chemotherapy
Autor: Lemoli, Roberto M. ; Martinelli, Giovanni ; Zamagni, Elena ; Motta, Maria Rosa ; Rizzi, Simonetta ; Terragna, Carolina ; Rondelli, Roberto ; Ronconi, Sonia ; Curti, Antonio ; Bonifazi, Francesca ; Tura, Sante ; Cavo, Michele
Assuntos: Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antigens, CD34 - analysis ; Antineoplastic Agents, Alkylating - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Busulfan - administration & dosage ; Disease-Free Survival ; Female ; Hematopoietic Stem Cell Transplantation ; Humans ; Male ; Medical sciences ; Melphalan - administration & dosage ; Middle Aged ; Multiple Myeloma - therapy ; Prognosis ; Remission Induction ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy ; Transplantation, Autologous ; Whole-Body Irradiation
É parte de: Blood, 2000-04, Vol.95 (7), p.2234-2239
Descrição: Eighty-two patients with advanced multiple myeloma (MM) were enrolled in 2 sequential clinical studies of 1 or 2 courses of myeloablative therapy with stem cell support. Conditioning regimens consisted of high-dose melphalan (MEL) with or without total body irradiation (TX1 = 35) and MEL as the first preparative regimen, followed within 6 months by busulfan and melphalan (TX2 = 47). On the basis of adequate stem cell harvest, 31 patients (TX1 = 13; TX2 = 18) were transplanted with highly purified CD34+ cells. Positively selected stem cells did not adversely affect hematopoietic reconstitution compared with unmanipulated peripheral blood stem cell. Overall, the complete remission (CR) rate of evaluative patients was 13.8% and 41% for single and double autotransplant, respectively (P = .04). Moreover, 3 patients undergoing TX2 achieved molecular remission and 2 remain PCR-negative after 36 and 24 months from autograft. The median event-free survival (EFS) durations for TX1 and TX2 were 17 and 35 months, respectively (P = .03). Actuarial 3-year overall survival for patients treated with 1 or 2 transplants are 76% and 92%, respectively (P = NS). On multivariate analysis, superior EFS was associated with low β2 microglobulin (β2-M) level at diagnosis and TX2, whereas overall survival was correlated with β2-M. Positive selection of CD34+ cells did not influence the achievement of clinical or molecular CR, as well as remission duration or survival of MM patients. Thus, whereas multiple cycles of high-dose therapy may be beneficial for patients with myeloma, the clinical impact of tumor cell purging remains highly questionable.
Editor: Washington, DC: Elsevier Inc
Idioma: Inglês

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Engraftment, clinical, and molecular follow-up of patients with multiple myeloma who were reinfused with highly purified CD34+ cells to support single or tandem high-dose chemotherapy

Lemoli, Roberto M. ; Martinelli, Giovanni ; Zamagni, Elena ; Motta, Maria Rosa ; Rizzi, Simonetta ; Terragna, Carolina ; Rondelli, Roberto ; Ronconi, Sonia ; Curti, Antonio ; Bonifazi, Francesca ; Tura, Sante ; Cavo, Michele

Washington, DC: Elsevier Inc

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