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Sudden cardiac death associated to substances of abuse and psychotropic drugs consumed by young people: A population study based on forensic autopsies

Morentin, Benito ; Callado, Luis F.

Drug and alcohol dependence, 2019-08, Vol.201, p.23-28 [Periódico revisado por pares]

Ireland: Elsevier B.V

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Sudden cardiac death associated to substances of abuse and psychotropic drugs consumed by young people: A population study based on forensic autopsies
Autor: Morentin, Benito ; Callado, Luis F.
Assuntos: Adolescent ; Adult ; Autopsies ; Autopsy ; Cannabis ; Cardiovascular disease ; Cardiovascular diseases ; Cause of Death ; Clinical research ; Cocaine ; Coronary artery disease ; Death ; Death & dying ; Death, Sudden, Cardiac - epidemiology ; Death, Sudden, Cardiac - etiology ; Drug abuse ; Drugs ; Drugs of abuse ; Ethanol ; Fatalities ; Female ; Females ; Forensic pathology ; Forensic science ; Forensic toxicology ; Hazardous materials ; Health risk assessment ; Health risks ; Heart diseases ; Humans ; Illicit Drugs - adverse effects ; Ischemia ; Male ; Males ; Marijuana ; Mortality ; Narcotics ; Population studies ; Prospective Studies ; Psychotropic drugs ; Psychotropic Drugs - adverse effects ; Risk analysis ; Risk Factors ; Sex differences ; Smoking ; Smoking - mortality ; Spain - epidemiology ; Substance abuse ; Substance-Related Disorders - complications ; Substance-Related Disorders - mortality ; Sudden cardiac death ; Sudden death ; Toxic substances ; Toxicology ; Young ; Young Adult ; Young adults ; Youth
É parte de: Drug and alcohol dependence, 2019-08, Vol.201, p.23-28
Descrição: •The presence of drugs of abuse is very high in young people’s sudden deaths.•Substances of abuse play an important role as triggers of sudden death in males.•Substances of abuse represent a higher risk than cardiovascular factors.•Tobacco followed by alcohol, cannabis and cocaine are the main substances consumed.•Influence of tobacco and cocaine is mainly important for ischemic heart disease. Toxic substances are one of the main risk factors for sudden cardiac death (SCD) in young people. However, there is limited information about this matter based on clinical research. The aim of this study was to analyze the use of substances of abuse (legal and illicit) and prescribed psychotropic drugs in young people who died by SCD. A population-based study performed in 15–35-year-olds who died by SCD in Biscay (Basque-Country) between 1991 and 2016. Cases were analyzed prospectively by a complete autopsy, toxicological and histopathological studies. A case was considered positive for exposure to cardiotoxic substances if smoking status was diagnosed or if toxicological analysis detected any drug associated with increased risk of SCD. There were 204 SCD; 98 (48%) were exposed to a cardiotoxic substance, including smoking status (n = 72) and/or positive toxicology (n = 58). Illicit drugs (n = 29, mainly cannabis and cocaine), ethanol (n = 25), and prescribed psychotropic drugs (n = 11) were detected. Positive cases were more frequent in males than in females (54% vs. 19%). They were also more common in subjects who died by acute (86%) and chronic (71%) ischemic heart disease than in myocardial diseases (33%) and sudden arrhythmic death syndrome (36%). All positive cases of illicit drugs were males. Smoking status was very high in deaths due to acute ischemic heart disease. The proportion of users of substances of abuse was unexpectedly high, even more prevalent than other cardiovascular risk factors. Toxic substances could play an important role as triggers of SCD in young people.
Editor: Ireland: Elsevier B.V
Idioma: Inglês

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Sudden cardiac death associated to substances of abuse and psychotropic drugs consumed by young people: A population study based on forensic autopsies

Morentin, Benito ; Callado, Luis F.

Ireland: Elsevier B.V

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