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Relationship between major and minor salivary gland mucoepidermoid carcinoma malignancy grading and presence of stromal myofibroblasts immunohistochemical study

Ana Paula Veras Sobral Silvia Vanessa L Loducca; Luiz Paulo Kowalski; Vera Cavalcanti de Araújo; Fábio Daumas Nunes; Ney Soares de Araújo

Journal of Oral Pathology and Medicine v. 33, n. 6, p.335-339, July 2004

Oxford 2004

Item não circula. Consulte sua biblioteca.(Acessar)

  • Título:
    Relationship between major and minor salivary gland mucoepidermoid carcinoma malignancy grading and presence of stromal myofibroblasts immunohistochemical study
  • Autor: Ana Paula Veras Sobral
  • Silvia Vanessa L Loducca; Luiz Paulo Kowalski; Vera Cavalcanti de Araújo; Fábio Daumas Nunes; Ney Soares de Araújo
  • Assuntos: IMUNOHISTOQUÍMICA; CARCINOMA; GLÂNDULAS SALIVARES
  • É parte de: Journal of Oral Pathology and Medicine v. 33, n. 6, p.335-339, July 2004
  • Descrição: OBJECTIVE: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary tumour, classified as low, intermediate and high grade. Myofibroblasts are the main stromal component and are included as prognostic factor in some tumours. The aim of this study was to evaluate the myofibroblasts in the stroma of MEC with possible relationship to malignancy grading. METHODS: Twenty-five cases of MEC (six low grade, 11 intermediate grade, four high grade and four metastasis) were stained for vimentin, desmin and smooth muscle actin (SMA) for the identification of myofibroblasts. Transforming growth factors (TGFbeta1 and TGF 'beta' RII) were also assessed in our study. RESULTS: Myofibroblasts were present in all cases, in amounts varying according to histological grading. TGFbeta1 was positive in squamous cells of intermediate grade tumours, and in the stroma of only four cases. TGF 'beta' RII was positive in most squamous and intermediate cells, regardless of malignancy grading. CONCLUSIONS: Our study showed that the analysis of neoplastic stroma must be added to the studies of neoplastic cells to draw a better picture leading to tumour diagnosis and prognosis
  • Editor: Oxford
  • Data de criação/publicação: 2004
  • Formato: p. 335-339.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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