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Influences of Verapamil, X-537A, A-23187 and Adenosine 3’, 5’-Cyclic Monophosphate on Release of 5-Hydroxytryptamine from Rat Brain Slices

Murakami, Hiroko ; Kaji, Eiko ; Segawa, Tomio

The Japanese Journal of Pharmacology, 1978, Vol.28(4), pp.589-596

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Título:
Influences of Verapamil, X-537A, A-23187 and Adenosine 3’, 5’-Cyclic Monophosphate on Release of 5-Hydroxytryptamine from Rat Brain Slices
Autor: Murakami, Hiroko ; Kaji, Eiko ; Segawa, Tomio
Assuntos: Animals ; Anti-Bacterial Agents - pharmacology ; Brain - metabolism ; Calcimycin - pharmacology ; Calcium - physiology ; Cyclic AMP - pharmacology ; In Vitro Techniques ; Lasalocid - pharmacology ; Male ; Potassium - pharmacology ; Rats ; Serotonin - metabolism ; Theophylline - pharmacology ; Verapamil - pharmacology
É parte de: The Japanese Journal of Pharmacology, 1978, Vol.28(4), pp.589-596
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Influences of verapamil, X-537A, A-23187 and cyclic-AMP on the release of [3H]-5-HT taken up into rat brain slices, were examined. Incubation with 40 mm KCl induced tritium release which was dependent on the presence of Ca2+. Verapamil, which blocks Ca2+ influx in excitable tissues, decreased potassium-induced release of 5-HT. Tritium release induced by ionophore X-537A was not dependent on extracellular Ca2+ while that induced by A-23187 required Ca2+. Cyclic-AMP, dibutyryl cyclic-AMP and theophylline did not significantly stimulate 5-HT release either in the presence or absence of Ca2+.
Editor: Japan: The Japanese Pharmacological Society
Idioma: Inglês

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