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Molecular evolution of Zika virus during its emergence in the 20(th) century

Faye, Oumar ; Freire, Caio C M ; Iamarino, Atila ; Faye, Ousmane ; de Oliveira, Juliana Velasco C ; Diallo, Mawlouth ; Zanotto, Paolo M A ; Sall, Amadou Alpha

PLoS neglected tropical diseases, 2014, Vol.8 (1), p.e2636-e2636 [Periódico revisado por pares]

United States: Public Library of Science (PLoS)

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Título:
Molecular evolution of Zika virus during its emergence in the 20(th) century
Autor: Faye, Oumar ; Freire, Caio C M ; Iamarino, Atila ; Faye, Ousmane ; de Oliveira, Juliana Velasco C ; Diallo, Mawlouth ; Zanotto, Paolo M A ; Sall, Amadou Alpha
Assuntos: Africa, Western - epidemiology ; Animals ; Cluster Analysis ; Evolution, Molecular ; Genetic Variation ; Humans ; Molecular Epidemiology ; Molecular Sequence Data ; Phylogeny ; Sequence Analysis, DNA ; Zika Virus - classification ; Zika Virus - genetics ; Zika Virus - isolation & purification ; Zika Virus Infection - epidemiology ; Zika Virus Infection - virology
É parte de: PLoS neglected tropical diseases, 2014, Vol.8 (1), p.e2636-e2636
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Zika virus (ZIKV) is a mosquito-borne flavivirus first isolated in Uganda in 1947. Although entomological and virologic surveillance have reported ZIKV enzootic activity in diverse countries of Africa and Asia, few human cases were reported until 2007, when a Zika fever epidemic took place in Micronesia. In the context of West Africa, the WHO Collaborating Centre for Arboviruses and Hemorrhagic Fever at Institut Pasteur of Dakar (http://www.pasteur.fr/recherche/banques/CRORA/) reports the periodic circulation of ZIKV since 1968. Despite several reports on ZIKV, the genetic relationships among viral strains from West Africa remain poorly understood. To evaluate the viral spread and its molecular epidemiology, we investigated 37 ZIKV isolates collected from 1968 to 2002 in six localities in Senegal and Côte d'Ivoire. In addition, we included strains from six other countries. Our results suggested that these two countries in West Africa experienced at least two independent introductions of ZIKV during the 20(th) century, and that apparently these viral lineages were not restricted by mosquito vector species. Moreover, we present evidence that ZIKV has possibly undergone recombination in nature and that a loss of the N154 glycosylation site in the envelope protein was a possible adaptive response to the Aedes dalzieli vector.
Editor: United States: Public Library of Science (PLoS)
Idioma: Inglês

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Molecular evolution of Zika virus during its emergence in the 20(th) century

Faye, Oumar ; Freire, Caio C M ; Iamarino, Atila ; Faye, Ousmane ; de Oliveira, Juliana Velasco C ; Diallo, Mawlouth ; Zanotto, Paolo M A ; Sall, Amadou Alpha

United States: Public Library of Science (PLoS)

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