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Human Olfaction without Apparent Olfactory Bulbs

Weiss, Tali ; Soroka, Timna ; Gorodisky, Lior ; Shushan, Sagit ; Snitz, Kobi ; Weissgross, Reut ; Furman-Haran, Edna ; Dhollander, Thijs ; Sobel, Noam

Neuron (Cambridge, Mass.), 2020-01, Vol.105 (1), p.35-45.e5 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Human Olfaction without Apparent Olfactory Bulbs
Autor: Weiss, Tali ; Soroka, Timna ; Gorodisky, Lior ; Shushan, Sagit ; Snitz, Kobi ; Weissgross, Reut ; Furman-Haran, Edna ; Dhollander, Thijs ; Sobel, Noam
Assuntos: Adult ; anosmia ; Brain architecture ; brain plasticity ; Coding ; Cortex (olfactory) ; Cortex (piriform) ; Cortex (somatosensory) ; Databases, Factual - statistics & numerical data ; Female ; Functional anatomy ; functional brain imaging ; Functional Laterality - physiology ; Functional magnetic resonance imaging ; Functional plasticity ; Handedness ; Humans ; left-handedness ; Magnetic Resonance Imaging ; Neuroimaging ; odor coding ; Olfaction ; Olfactory bulb ; Olfactory Bulb - pathology ; Olfactory discrimination ; Olfactory discrimination learning ; olfactory perception ; Olfactory Perception - physiology ; Piriform Cortex - physiology ; Sensory evaluation ; Sex Characteristics ; Smell ; structural brain imaging ; Studies ; Ultrastructure ; Women
É parte de: Neuron (Cambridge, Mass.), 2020-01, Vol.105 (1), p.35-45.e5
Notas: ObjectType-Case Study-2
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These authors contributed equally
Descrição: The olfactory bulbs (OBs) are the first site of odor representation in the mammalian brain, and their unique ultrastructure is considered a necessary substrate for spatiotemporal coding of smell. Given this, we were struck by the serendipitous observation at MRI of two otherwise healthy young left-handed women, yet with no apparent OBs. Standardized tests revealed normal odor awareness, detection, discrimination, identification, and representation. Functional MRI of these women’s brains revealed that odorant-induced activity in piriform cortex, the primary OB target, was similar in its extent to that of intact controls. Finally, review of a public brain-MRI database with 1,113 participants (606 women) also tested for olfactory performance, uncovered olfaction without anatomically defined OBs in ∼0.6% of women and ∼4.25% of left-handed women. Thus, humans can perform the basic facets of olfaction without canonical OBs, implying extreme plasticity in the functional neuroanatomy of this sensory system. •Humans can have normal olfaction without apparent olfactory bulbs•Olfaction without apparent bulbs is seen in 0.6% of women, but not in men•Olfaction without apparent bulbs is associated with left-handedness The olfactory bulbs are the sole known relay station of odor information from nose to brain. Using MRI, Weiss et al. discover that ∼4% of left-handed women have normal olfaction without apparent olfactory bulbs. How these women can smell remains unknown.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Human Olfaction without Apparent Olfactory Bulbs

Weiss, Tali ; Soroka, Timna ; Gorodisky, Lior ; Shushan, Sagit ; Snitz, Kobi ; Weissgross, Reut ; Furman-Haran, Edna ; Dhollander, Thijs ; Sobel, Noam

United States: Elsevier Inc

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