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Review on pediatric coeliac disease from a clinical perspective

Wessels, Margreet ; Auricchio, Renata ; Dolinsek, Jernej ; Donat, Ester ; Gillett, Peter ; Mårild, Karl ; Meijer, Caroline ; Popp, Alina ; Mearin, M Luisa

European journal of pediatrics, 2022-05, Vol.181 (5), p.1785-1795 [Periódico revisado por pares]

Berlin/Heidelberg: Springer Berlin Heidelberg

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Título:
Review on pediatric coeliac disease from a clinical perspective
Autor: Wessels, Margreet ; Auricchio, Renata ; Dolinsek, Jernej ; Donat, Ester ; Gillett, Peter ; Mårild, Karl ; Meijer, Caroline ; Popp, Alina ; Mearin, M Luisa
Assuntos: Adult ; Atrophy ; Autoantibodies ; autoimmune thyroid-disease ; Biopsy ; Celiac disease ; Celiac Disease - diagnosis ; Celiac Disease - epidemiology ; Celiac Disease - etiology ; Child ; Children ; Children and adolescents ; Coeliac disease ; Diagnosis ; Diet ; Environmental factors ; Epidemiology ; Follow-up ; Gluten ; gluten-free diet ; Glutens ; Histocompatibility antigen HLA ; Histocompatibility Testing ; Humans ; Immune response ; increased ; infection ; Intestine, Small - pathology ; larazotide acetate ; Malabsorption ; Medicine ; Medicine & Public Health ; Pediatrics ; Pediatrik ; prevalence ; Quality of Life ; Review ; risk ; Risk groups ; Tissue typing ; Transglutaminase 2 ; villous atrophy
É parte de: European journal of pediatrics, 2022-05, Vol.181 (5), p.1785-1795
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Coeliac disease is an immune-mediated condition characterized by chronic inflammation of the small bowel with villous atrophy driven by gluten ingestion in genetically predisposed individuals. It occurs frequently in both children and adults, affecting 1–4% of the population. The disease is associated with both gastrointestinal and extra-intestinal symptoms related to malabsorption and/or immune activation, and autoantibodies to tissue transglutaminase. Removal of gluten from the diet results in resolution of symptoms and enteropathy in the majority of patients. A good diagnostic work-up is important to avoid unnecessary restrictive diets in children. In this review on pediatric coeliac disease, we address epidemiology including predisposing environmental factors and possible preventive strategies, as well as the clinical presentation, diagnosis and follow-up. What is Known: •Primary prevention of coeliac disease is not possible; however, secondary prevention by targeting high-risk groups is recommended. •The diagnosis is safe without duodenal biopsies if specific conditions are met, also in asymptomatic children. What is New: •HLA-DQ typing is not routinely required for the diagnosis, whereas it can rule out coeliac disease if HLA-DQ2 and HLA-DQ8 are absent. •Follow-up could be improved by a more rational use of (laboratory) tests, increased intention to dietary compliance and quality of life.
Editor: Berlin/Heidelberg: Springer Berlin Heidelberg
Idioma: Inglês

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Review on pediatric coeliac disease from a clinical perspective

Wessels, Margreet ; Auricchio, Renata ; Dolinsek, Jernej ; Donat, Ester ; Gillett, Peter ; Mårild, Karl ; Meijer, Caroline ; Popp, Alina ; Mearin, M Luisa

Berlin/Heidelberg: Springer Berlin Heidelberg

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