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Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial

Bruno Gualano Carlos Ugrinowitsch; Rafael Batista Novaes; G. G Artioli (Guilherme Giannini); Maria Heloisa Shimizu; Antonio Carlos Seguro; Roger Charles Harris; Antonio Herbert Lancha Junior

European Journal of Applied Physiology Berlin v. 103, n. 1, p. 33-40, maio 2008

Berlin 2008

Acesso online. A biblioteca também possui exemplares impressos.

  • Título:
    Effects of creatine supplementation on renal function: a randomized, double-blind, placebo-controlled clinical trial
  • Autor: Bruno Gualano
  • Carlos Ugrinowitsch; Rafael Batista Novaes; G. G Artioli (Guilherme Giannini); Maria Heloisa Shimizu; Antonio Carlos Seguro; Roger Charles Harris; Antonio Herbert Lancha Junior
  • Assuntos: NUTRIÇÃO; SUPLEMENTAÇÃO ALIMENTAR; PLACEBOS; EXERCÍCIO FÍSICO
  • É parte de: European Journal of Applied Physiology Berlin v. 103, n. 1, p. 33-40, maio 2008
  • Notas: Disponível em: http://www.springerlink.com.w10077.dotlib.com.br/content/m570621w6534k1l4/fulltext.pdf
  • Descrição: Creatine (CR) supplementation is commonly used by athletes. However, its eVects on renal function remain controversial. The aim of this study was to evaluate the eVects of creatine supplementation on renal function in healthy sedentary males (18-35 years old) submitted to exercise training. A randomized, double-blind, placebo-controlled trial was performed. Subjects (n = 18) were randomly allocated to receive treatment with either creatine (CR) ("10 g day¡1 over 3 months) or placebo (PL) (dextrose). All subjects undertook moderate intensity aerobic training, in three 40-min sessions per week, during 3 months. Serum creatinine, serum and urinary sodium and potassium were determined at baseline and at the end of the study. Cystatin C was assessed prior to training (PRE), after 4 (POST 4) and 12 weeks (POST 12). Cystatin C levels (mg L¡1) (PRE CR: 0.82 § 0.09; PL: 0.88 § 0.07 vs. POST 12 CR: 0.71 § 0.06; PL: 0.75 § 0.09, P = 0.0001) were decreased over time, suggesting an increase in glomerular Wltration rate. Serum creatinine decreased with training in PL but was unchanged with training in CR. No signiWcant diVerences were observed within or between groups in other parameters investigated. The decrease in cystatin C indicates that highdose creatine supplementation over 3 months does not provoke any renal dysfunction in healthy males undergoing aerobic training. In addition, the results suggest that moderate aerobic training per se may improve renal function
  • Editor: Berlin
  • Data de criação/publicação: 2008
  • Formato: p. 33-40.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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