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Combined analysis of cytoarchitectonic, molecular and transcriptomic patterns reveal differences in brain organization across human functional brain systems

Zachlod, Daniel ; Bludau, Sebastian ; Cichon, Sven ; Palomero-Gallagher, Nicola ; Amunts, Katrin

NeuroImage (Orlando, Fla.), 2022-08, Vol.257, p.119286-119286, Article 119286 [Periódico revisado por pares]

United States: Elsevier Inc

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Combined analysis of cytoarchitectonic, molecular and transcriptomic patterns reveal differences in brain organization across human functional brain systems
Autor: Zachlod, Daniel ; Bludau, Sebastian ; Cichon, Sven ; Palomero-Gallagher, Nicola ; Amunts, Katrin
Assuntos: Allen Human Brain Atlas ; Binding sites ; Brain ; Brain architecture ; cortical organization ; cytoarchitecture ; Disease ; Functional morphology ; Gene expression ; Glutamatergic transmission ; Glutamic acid receptors (ionotropic) ; Julich-Brain atlas ; Ligands ; Motor systems ; N-Methyl-D-aspartic acid receptors ; Proteins ; receptor architecture ; Receptor density ; Sensorimotor integration ; Sensory integration ; Signal transduction ; Structure-function relationships ; Transcriptomics ; Values ; γ-Aminobutyric acid A receptors
É parte de: NeuroImage (Orlando, Fla.), 2022-08, Vol.257, p.119286-119286, Article 119286
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Descrição: Brain areas show specific cellular, molecular, and gene expression patterns that are linked to function, but their precise relationships are largely unknown. To unravel these structure-function relationships, a combined analysis of 53 neurotransmitter receptor genes, receptor densities of six transmitter systems and cytoarchitectonic data of the auditory, somatosensory, visual, motor systems was conducted. Besides covariation of areal gene expression with receptor density, the study reveals specific gene expression patterns in functional systems, which are most prominent for the inhibitory GABAA and excitatory glutamatergic NMDA receptors. Furthermore, gene expression-receptor relationships changed in a systematic manner according to information flow from primary to higher associative areas. The findings shed new light on the relationship of anatomical, functional, and molecular and transcriptomic principles of cortical segregation towards a more comprehensive understanding of human brain organization.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Combined analysis of cytoarchitectonic, molecular and transcriptomic patterns reveal differences in brain organization across human functional brain systems

Zachlod, Daniel ; Bludau, Sebastian ; Cichon, Sven ; Palomero-Gallagher, Nicola ; Amunts, Katrin

United States: Elsevier Inc

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