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537 Integrative analysis of DCE-MRI and gene expression profiles in patients with cervical cancer undergoing pelvic exenteration

Valstad, Hanna ; Hompland, Tord ; Fjeldbo, Christina S ; Skeie-Jensen, Tone ; Eyjolfsdottir, Brynhildur ; Kristensen, Gunnar B ; Lund, Kjersti V ; Lyng, Heidi ; Lindemann, Kristina

International journal of gynecological cancer, 2024-03, Vol.34 (Suppl 1), p.A499-A500 [Periódico revisado por pares]

Oxford: BMJ Publishing Group Ltd

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  • Título:
    537 Integrative analysis of DCE-MRI and gene expression profiles in patients with cervical cancer undergoing pelvic exenteration
  • Autor: Valstad, Hanna ; Hompland, Tord ; Fjeldbo, Christina S ; Skeie-Jensen, Tone ; Eyjolfsdottir, Brynhildur ; Kristensen, Gunnar B ; Lund, Kjersti V ; Lyng, Heidi ; Lindemann, Kristina
  • Assuntos: Cervical cancer ; Gene expression ; Magnetic resonance imaging ; Poster and E-Posters
  • É parte de: International journal of gynecological cancer, 2024-03, Vol.34 (Suppl 1), p.A499-A500
  • Notas: ESGO 2024 Congress Abstracts
    11. Translational research/biomarkers
  • Descrição: Introduction/BackgroundPatients with cervical cancer undergoing pelvic exenteration still face poor prognosis as almost half of the patients recur. There is a clear need for better understanding of prognostic biomarkers to identify those patients with a high likelihood to benefit from exenterative surgery.MethodologyThis retrospective cohort study included 19 patients with cervical cancer treated with pelvic exenteration at Oslo University Hospital (OUH). All patients had diagnostic dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) and accessible tumour material for gene expression profiling. The image parameters Ktrans and ve (fractional volume), reflecting tumor perfusion and extracellular extravascular space, respectively, were calculated for each voxel of the DCE-MR images, using the Tofts pharmacokinetic model. RNA was extracted from paraffin-embedded tissue and analysed with RNA-sequencing, using the QuantSeq technology. Gene expression profiles of patients with and without recurrence were compared, and the differentially expressed genes were subjected to gene set enrichment analysis (GSEA). Clinical data including complete follow up was available in the quality assurance database.ResultsAfter a median follow up time of 5 years for non-recurrent patients, 10 patients had recurred. There was no significant association between tumor volume and recurrence. Patients with recurrence had significantly higher Ktrans on DCE-MRI compared to patients without recurrence (p=0.002). There was no significant difference in ve between the two patient groups. Totally 62 genes were found to be significantly upregulated and 17 genes were downregulated in patients with recurrence. GSEA analysis of the upregulated genes showed significant enrichment of biological processes related to vascular function.ConclusionIncreased tumor perfusion measured on DCE-MRI is a possible poor prognostic factor for patients with cervical cancer undergoing pelvic exenteration. Gene expression pattern supports this role of neovascularization and abnormal blood vessels in prognosis. If these findings can be validated, this may help to select patients to exenterative surgery.DisclosuresKL: Receipt of grants/research supports: GSK, research funding paid toInstitution; Receipt of honoraria or consultation fees: Advisory board fees: Astra Zeneca, Nycode, GSK, EisaiGK: Stockholder: Novo NordicAbstract 537 Figure 1
  • Editor: Oxford: BMJ Publishing Group Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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