Idioma:

Clinicopathologic Correlation of C1q Nephropathy in Children

Fukuma, Yuko ; Hisano, Satoshi ; Segawa, Yoshie ; Niimi, Kazuhiko ; Tsuru, Noboru ; Kaku, Yoshitsugu ; Hatae, Ken ; Kiyoshi, Yasuhiro ; Mitsudome, Akihisa ; Iwasaki, Hiroshi

American journal of kidney diseases, 2006-03, Vol.47 (3), p.412-418 [Periódico revisado por pares]

Orlando, FL: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Clinicopathologic Correlation of C1q Nephropathy in Children
Autor: Fukuma, Yuko ; Hisano, Satoshi ; Segawa, Yoshie ; Niimi, Kazuhiko ; Tsuru, Noboru ; Kaku, Yoshitsugu ; Hatae, Ken ; Kiyoshi, Yasuhiro ; Mitsudome, Akihisa ; Iwasaki, Hiroshi
Assuntos: Adolescent ; Biological and medical sciences ; C1q nephropathy ; Child ; Child, Preschool ; Complement C1q ; Female ; focal segmental glomerulosclerosis ; frequent relapsing nephrotic syndrome ; Glomerulonephritis ; Glomerulosclerosis, Focal Segmental - diagnosis ; Glomerulosclerosis, Focal Segmental - immunology ; Glomerulosclerosis, Focal Segmental - therapy ; Humans ; Male ; Medical sciences ; minimal change disease ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nephrosis, Lipoid - diagnosis ; Nephrosis, Lipoid - immunology ; Nephrosis, Lipoid - therapy ; Nephrotic Syndrome - diagnosis ; Nephrotic Syndrome - immunology ; Nephrotic Syndrome - therapy
É parte de: American journal of kidney diseases, 2006-03, Vol.47 (3), p.412-418
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Background: Clinicopathologic correlation of C1q nephropathy is clarified poorly. The aim of our study is to clarify clinicopathologic correlation in childhood C1q nephropathy. Methods: Thirty children aged 3 to 15 years who met criteria proposed by Jennette and Hipp were enrolled in this study. Results: According to their presentation at onset, children were divided into 2 groups: the asymptomatic urinary abnormalities (asymptomatic) group (n = 18) and the nephrotic syndrome (NS) group (n = 12). Light microscopy showed minimal change disease (MCD) in 22 children (73%), mesangial proliferative glomerulonephritis in 6 children (20%), and focal segmental glomerulosclerosis (FSGS) in 2 children (7%). Four children in the asymptomatic group and all children in the NS group were administered prednisolone and/or cyclosporine. Normal urinalysis results were found in 8 children in the asymptomatic group and 3 children in the NS group during the follow-up period of 3 to 15 years. Eight children in the NS group were frequent relapsers at the latest follow-up. Two children with FSGS (1 child, asymptomatic group; 1 child, NS group) received dialysis 10 and 15 years after the diagnosis. There were no differences in histological findings and clinical outcomes between the 2 groups. Four children with MCD in the NS group underwent a second biopsy. C1q deposits disappeared in 2 children, and 1 of these 2 children showed FSGS. Conclusion: Childhood C1q nephropathy is found in a wide clinical spectrum. Some children showed disappearance of C1q deposits through the follow-up period. A large number of children with C1q nephropathy showed MCD. However, FSGS may develop in some children on repeated biopsy. Therefore, long-term follow-up is needed in children with C1q nephropathy.
Editor: Orlando, FL: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Clinicopathologic Correlation of C1q Nephropathy in Children

Fukuma, Yuko ; Hisano, Satoshi ; Segawa, Yoshie ; Niimi, Kazuhiko ; Tsuru, Noboru ; Kaku, Yoshitsugu ; Hatae, Ken ; Kiyoshi, Yasuhiro ; Mitsudome, Akihisa ; Iwasaki, Hiroshi

Orlando, FL: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.