Idioma:

Genital Inflammation and the Risk of HIV Acquisition in Women

Masson, Lindi ; Passmore, Jo-Ann S. ; Liebenberg, Lenine J. ; Werner, Lise ; Baxter, Cheryl ; Arnold, Kelly B. ; Wiliamson, Carolyn ; Little, Francesca ; Mansoor, Leila E. ; Naranbhai, Vivek ; Lauffenburger, Douglas A. ; Ronacher, Katharina ; Walzi, Gerhard ; Garrett, Nigel J. ; Williams, Brent L. ; Couto-Rodriguez, Mara ; Hornig, Mady ; Lipkin, W. Ian ; Grobler, Anneke ; Karim, Quarraisha Abdool ; Karim, Salim S. Abdool

Clinical infectious diseases, 2015-07, Vol.61 (2), p.260-269 [Periódico revisado por pares]

United States: Oxford University Press

Texto completo disponível

Citações Citado por

Enviar para

Título:
Genital Inflammation and the Risk of HIV Acquisition in Women
Autor: Masson, Lindi ; Passmore, Jo-Ann S. ; Liebenberg, Lenine J. ; Werner, Lise ; Baxter, Cheryl ; Arnold, Kelly B. ; Wiliamson, Carolyn ; Little, Francesca ; Mansoor, Leila E. ; Naranbhai, Vivek ; Lauffenburger, Douglas A. ; Ronacher, Katharina ; Walzi, Gerhard ; Garrett, Nigel J. ; Williams, Brent L. ; Couto-Rodriguez, Mara ; Hornig, Mady ; Lipkin, W. Ian ; Grobler, Anneke ; Karim, Quarraisha Abdool ; Karim, Salim S. Abdool
Assuntos: Africa ; Cervix Uteri - immunology ; Chemokine CCL2 - analysis ; Chemokine CCL2 - blood ; Chemokine CCL2 - immunology ; Chemokines - analysis ; Chemokines - blood ; Chemokines - genetics ; Chemokines - immunology ; Cytokines ; Cytokines - analysis ; Cytokines - blood ; Cytokines - genetics ; Cytokines - immunology ; Disease Susceptibility ; Female ; Genital Diseases, Female - diagnosis ; Genitalia, Female - immunology ; Genitalia, Female - virology ; HIV ; HIV Infections - immunology ; HIV Infections - transmission ; HIV Infections - virology ; HIV/AIDS ; Human immunodeficiency virus ; Humans ; Inflammation - diagnosis ; Inflammatory diseases ; Interferon ; Interferon-gamma - analysis ; Interferon-gamma - blood ; Interferon-gamma - immunology ; Interleukin-10 - analysis ; Interleukin-10 - immunology ; Interleukin-6 - analysis ; Interleukin-6 - blood ; Interleukin-6 - immunology ; Interleukin-8 - analysis ; Interleukin-8 - blood ; Interleukin-8 - immunology ; Sexually Transmitted Diseases ; South Africa ; Tumor Necrosis Factor-alpha - analysis ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - immunology ; Urogenital system ; Uterine Cervicitis - diagnosis ; Vagina - immunology ; Vaginal Douching ; Vaginitis - diagnosis ; Women ; Young Adult
É parte de: Clinical infectious diseases, 2015-07, Vol.61 (2), p.260-269
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
L. M., J.-A. S. P., and L. J. L. contributed equally to the preparation of this manuscript.
Descrição: Background. Women in Africa, especially young women, have very high human immunodeficiency virus (HIV) incidence rates that cannot be fully explained by behavioral risks. We investigated whether genital inflammation influenced HIV acquisition in this group. Methods. Twelve selected cytokines, including 9 inflammatory cytokines and chemokines (interleukin [IL]-1α, IL-1β, IL-6, tumor necrosis factor-α, IL-8, interferon-γ inducible protein-10 [IP-10], monocyte chemoattractant protein-1, macrophage inflammatory protein [MIP]-1α, MIP-1β), hematopoietic IL-7, and granulocyte macrophage colony-stimulating factor, and regulatory IL-10 were measured prior to HIV infection in cervicovaginal lavages from 58 HIV seroconverters and 58 matched uninfected controls and in plasma from a subset of 107 of these women from the Centre for the AIDS Programme of Research in South Africa 004 tenofovir gel trial. Results. HIV seroconversion was associated with raised genital inflammatory cytokines (including chemokines MIP-1α, MIP-1β, and IP-10). The risk of HIV acquisition was significantly higher in women with evidence of genital inflammation, defined by at least 5 of 9 inflammatory cytokines being raised (odds ratio, 3.2; 95% confidence interval, 1.3–7.9; P = .014). Genital cytokine concentrations were persistently raised (for about 1 year before infection), with no readily identifiable cause despite extensive investigation of several potential factors, including sexually transmitted infections and systemic cytokines. Conclusions. Elevated genital concentrations of HIV target cell–recruiting chemokines and a genital inflammatory profile contributes to the high risk of HIV acquisition in these African women.
Editor: United States: Oxford University Press
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Genital Inflammation and the Risk of HIV Acquisition in Women

United States: Oxford University Press

Buscando em bases de dados remotas. Favor aguardar.