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Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial

Hayward, Andrew C ; Harling, Richard ; Wetten, Sally ; Johnson, Anne M ; Munro, Susan ; Smedley, Julia ; Murad, Shahed ; Watson, John M

BMJ, 2006-12, Vol.333 (7581), p.1241-1244 [Periódico revisado por pares]

London: British Medical Journal Publishing Group

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Título:
Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial
Autor: Hayward, Andrew C ; Harling, Richard ; Wetten, Sally ; Johnson, Anne M ; Munro, Susan ; Smedley, Julia ; Murad, Shahed ; Watson, John M
Assuntos: Aged ; Biological and medical sciences ; Clinical outcomes ; Clinical trials ; Diseases ; General aspects ; Health outcomes ; Health Policy ; Health Services - statistics & numerical data ; Home care services ; Homes ; Homes for the Aged - statistics & numerical data ; Hospital admissions ; Human viral diseases ; Humans ; Immunization ; Immunization Programs ; Infectious Disease Transmission, Professional-to-Patient - prevention & control ; Infectious diseases ; Influenza ; Influenza Vaccines ; Influenza, Human - mortality ; Influenza, Human - prevention & control ; Medical personnel ; Medical sciences ; Mortality ; Nursing homes ; Nursing Homes - statistics & numerical data ; Occupational Diseases - prevention & control ; Occupational Health ; Older adults ; Prevention and actions ; Psychoeducational intervention ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Treatment Outcome ; Vaccination ; Viral diseases ; Viral diseases of the respiratory system and ent viral diseases
É parte de: BMJ, 2006-12, Vol.333 (7581), p.1241-1244
Notas: istex:CFF3AA0C11E1CA67C59AFA37E42D33347B6605B4
PMID:17142257
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Forest plots for rate differences during year 1 are on bmj.com
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ArticleID:haya368241
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Descrição: Objective To determine whether vaccination of care home staff against influenza indirectly protects residents. Design Pair matched cluster randomised controlled trial. Setting Large private chain of UK care homes during the winters of 2003-4 and 2004-5. Participants Nursing home staff (n=1703) and residents (n=2604) in 44 care homes (22 intervention homes and 22 matched control homes). Interventions Vaccination offered to staff in intervention homes but not in control homes. Main outcome measures The primary outcome was all cause mortality of residents. Secondary outcomes were influenza-like illness and health service use in residents. Results In 2003-4 vaccine coverage in full time staff was 48.2% (407/884) in intervention homes and 5.9% (51/859) in control homes. In 2004-5 uptake rates were 43.2% (365/844) and 3.5% (28/800). National influenza rates were substantially below average in 2004-5. In the 2003-4 period of influenza activity significant decreases were found in mortality of residents in intervention homes compared with control homes (rate difference −5.0 per 100 residents, 95% confidence interval −7.0 to −2.0) and in influenza-like illness (P=0.004), consultations with general practitioners for influenza-like illness (P=0.008), and admissions to hospital with influenza-like illness (P=0.009). No significant differences were found in 2004-5 or during periods of no influenza activity in 2003-4. Conclusions Vaccinating care home staff against influenza can prevent deaths, health service use, and influenza-like illness in residents during periods of moderate influenza activity. Trial registration National Research Register N0530147256.
Editor: London: British Medical Journal Publishing Group
Idioma: Inglês

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Effectiveness of an influenza vaccine programme for care home staff to prevent death, morbidity, and health service use among residents: cluster randomised controlled trial

Hayward, Andrew C ; Harling, Richard ; Wetten, Sally ; Johnson, Anne M ; Munro, Susan ; Smedley, Julia ; Murad, Shahed ; Watson, John M

London: British Medical Journal Publishing Group

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