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Mito-Nuclear Interactions Affecting Lifespan and Neurodegeneration in a Drosophila Model of Leigh Syndrome

Loewen, Carin A ; Ganetzky, Barry

Genetics (Austin), 2018-04, Vol.208 (4), p.1535-1552 [Periódico revisado por pares]

United States: Genetics Society of America

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Mito-Nuclear Interactions Affecting Lifespan and Neurodegeneration in a Drosophila Model of Leigh Syndrome
Autor: Loewen, Carin A ; Ganetzky, Barry
Assuntos: Age ; Animals ; Biological evolution ; Biomarkers ; Cell Nucleus - genetics ; Cell Nucleus - metabolism ; Deoxyribonucleic acid ; Disease ; Disease Models, Animal ; DNA ; DNA, Mitochondrial ; Drosophila ; Drosophila - genetics ; Drosophila - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Electron transport chain ; Gene Dosage ; Genes ; Genetic Association Studies ; Genetic variability ; Genomes ; Immunohistochemistry ; Insects ; Investigations ; Kinases ; Leigh Disease - etiology ; Leigh Disease - metabolism ; Life span ; Longevity ; Metabolism ; Mitochondria ; Mitochondria - genetics ; Mitochondria - metabolism ; Mitochondrial DNA ; Mutants ; Mutation ; NADH Dehydrogenase - genetics ; NADH Dehydrogenase - metabolism ; Neurodegeneration ; Neurodegenerative Diseases - etiology ; Neurodegenerative Diseases - metabolism ; Neurons - metabolism ; Nuclear interactions ; Phenotype ; Phenotypes ; Phosphorylation ; Proteins ; Signal Transduction
É parte de: Genetics (Austin), 2018-04, Vol.208 (4), p.1535-1552
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SourceType-Scholarly Journals-1
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Descrição: Proper mitochondrial activity depends upon proteins encoded by genes in the nuclear and mitochondrial genomes that must interact functionally and physically in a precisely coordinated manner. Consequently, mito-nuclear allelic interactions are thought to be of crucial importance on an evolutionary scale, as well as for manifestation of essential biological phenotypes, including those directly relevant to human disease. Nonetheless, detailed molecular understanding of mito-nuclear interactions is still lacking, and definitive examples of such interactions are sparse. Here we describe the characterization of a mutation in , a nuclear gene encoding a highly conserved subunit of mitochondrial complex 1. This characterization led to the discovery of a mito-nuclear interaction that affects the mutant phenotype. mutants exhibit reduced lifespan, neurodegeneration, abnormal mitochondrial morphology, and decreased ATP levels. These phenotypes are similar to those observed in patients with Leigh syndrome, which is caused by mutations in a number of nuclear genes that encode mitochondrial proteins, including the human ortholog of A key feature of Leigh syndrome, and other mitochondrial disorders, is unexpected and unexplained phenotypic variability. We discovered that the phenotypic severity of mutations varies depending on the maternally inherited mitochondrial background. Sequence analysis of the relevant mitochondrial genomes identified several variants that are likely candidates for the phenotypic interaction with mutant , including a variant affecting a mitochondrially encoded component of complex I. Thus, our work provides an demonstration of the phenotypic importance of mito-nuclear interactions in the context of mitochondrial disease.
Editor: United States: Genetics Society of America
Idioma: Inglês

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Mito-Nuclear Interactions Affecting Lifespan and Neurodegeneration in a Drosophila Model of Leigh Syndrome

Loewen, Carin A ; Ganetzky, Barry

United States: Genetics Society of America

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