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Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain

Zubieta, Jon-Kar ; Smith, Yolanda R. ; Bueller, Joshua A. ; Xu, Yanjun ; Kilbourn, Michael R. ; Jewett, Douglas M. ; Meyer, Charles R. ; Koeppe, Robert A. ; Stohler, Christian S.

Science (American Association for the Advancement of Science), 2001-07, Vol.293 (5528), p.311-315 [Periódico revisado por pares]

Washington, DC: American Society for the Advancement of Science

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Título:
Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain
Autor: Zubieta, Jon-Kar ; Smith, Yolanda R. ; Bueller, Joshua A. ; Xu, Yanjun ; Kilbourn, Michael R. ; Jewett, Douglas M. ; Meyer, Charles R. ; Koeppe, Robert A. ; Stohler, Christian S.
Assuntos: Adult ; Amygdala ; Amygdala - physiology ; Analgesics, Opioid - administration & dosage ; Behavioral psychophysiology ; Biological and medical sciences ; Brain ; Brain - physiology ; Brain Mapping ; Coordinate systems ; Female ; Fentanyl - administration & dosage ; Fentanyl - analogs & derivatives ; Fundamental and applied biological sciences. Psychology ; Humans ; Magnetic Resonance Imaging ; Male ; Masseter Muscle ; Nervous system ; Neurotransmission and behavior ; Nucleus accumbens ; Opioid analgesics ; Opioid Peptides - physiology ; Opioid receptors ; Opioids ; Pain ; Pain Measurement ; Physiological regulation ; Placebos ; Prefrontal cortex ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Receptors ; Receptors, Opioid, mu - physiology ; Thalamus ; Thalamus - physiology ; Tomography, Emission-Computed
É parte de: Science (American Association for the Advancement of Science), 2001-07, Vol.293 (5528), p.311-315
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-News-3
Descrição: The endogenous opioid system is involved in stress responses, in the regulation of the experience of pain, and in the action of analgesic opiate drugs. We examined the function of the opioid system and µ-opioid receptors in the brains of healthy human subjects undergoing sustained pain. Sustained pain induced the regional release of endogenous opioids interacting with µ-opioid receptors in a number of cortical and subcortical brain regions. The activation of the µ-opioid receptor system was associated with reductions in the sensory and affective ratings of the pain experience, with distinct neuroanatomical involvements. These data demonstrate the central role of the µ-opioid receptors and their endogenous ligands in the regulation of sensory and affective components of the pain experience.
Editor: Washington, DC: American Society for the Advancement of Science
Idioma: Inglês

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Regional Mu Opioid Receptor Regulation of Sensory and Affective Dimensions of Pain

Zubieta, Jon-Kar ; Smith, Yolanda R. ; Bueller, Joshua A. ; Xu, Yanjun ; Kilbourn, Michael R. ; Jewett, Douglas M. ; Meyer, Charles R. ; Koeppe, Robert A. ; Stohler, Christian S.

Washington, DC: American Society for the Advancement of Science

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