Idioma:

Development of focal segmental glomerulosclerosis after anabolic steroid abuse

Herlitz, Leal C ; Markowitz, Glen S ; Farris, Alton B ; Schwimmer, Joshua A ; Stokes, Michael B ; Kunis, Cheryl ; Colvin, Robert B ; D'Agati, Vivette D

Journal of the American Society of Nephrology, 2010-01, Vol.21 (1), p.163-172 [Periódico revisado por pares]

United States: American Society of Nephrology

Texto completo disponível

Citações Citado por

Enviar para

Título:
Development of focal segmental glomerulosclerosis after anabolic steroid abuse
Autor: Herlitz, Leal C ; Markowitz, Glen S ; Farris, Alton B ; Schwimmer, Joshua A ; Stokes, Michael B ; Kunis, Cheryl ; Colvin, Robert B ; D'Agati, Vivette D
Assuntos: Adult ; Anabolic Agents - adverse effects ; Biopsy ; Clinical Research ; Glomerulosclerosis, Focal Segmental - chemically induced ; Glomerulosclerosis, Focal Segmental - diagnosis ; Humans ; Kidney - pathology ; Male ; Middle Aged ; Proteinuria - chemically induced ; Proteinuria - diagnosis ; Renal Insufficiency - chemically induced ; Renal Insufficiency - diagnosis ; Steroids - adverse effects ; Substance-Related Disorders - complications
É parte de: Journal of the American Society of Nephrology, 2010-01, Vol.21 (1), p.163-172
Descrição: Anabolic steroid abuse adversely affects the endocrine system, blood lipids, and the liver, but renal injury has not been described. We identified an association of focal segmental glomerulosclerosis (FSGS) and proteinuria in a cohort of 10 bodybuilders (six white and four Hispanic; mean body mass index 34.7) after long-term abuse of anabolic steroids. The clinical presentation included proteinuria (mean 10.1 g/d; range 1.3 to 26.3 g/d) and renal insufficiency (mean serum creatinine 3.0 mg/dl; range 1.3 to 7.8 mg/dl); three (30%) patients presented with nephrotic syndrome. Renal biopsy revealed FSGS in nine patients, four of whom also had glomerulomegaly, and glomerulomegaly alone in one patient. Three biopsies revealed collapsing lesions of FSGS, four had perihilar lesions, and seven showed > or =40% tubular atrophy and interstitial fibrosis. Among eight patients with mean follow-up of 2.2 yr, one progressed to ESRD, the other seven received renin-angiotensin system blockade, and one also received corticosteroids. All seven patients discontinued anabolic steroids, leading to weight loss, stabilization or improvement in serum creatinine, and a reduction in proteinuria. One patient resumed anabolic steroid abuse and suffered relapse of proteinuria and renal insufficiency. We hypothesize that secondary FSGS results from a combination of postadaptive glomerular changes driven by increased lean body mass and potential direct nephrotoxic effects of anabolic steroids. Because of the expected rise in serum creatinine as a result of increased muscle mass in bodybuilders, this complication is likely underrecognized.
Editor: United States: American Society of Nephrology
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Development of focal segmental glomerulosclerosis after anabolic steroid abuse

Herlitz, Leal C ; Markowitz, Glen S ; Farris, Alton B ; Schwimmer, Joshua A ; Stokes, Michael B ; Kunis, Cheryl ; Colvin, Robert B ; D'Agati, Vivette D

United States: American Society of Nephrology

Buscando em bases de dados remotas. Favor aguardar.