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Neutral Theory, Microbial Practice: Challenges in Bacterial Population Genetics

Rocha, Eduardo P C Kumar, Sudhir

Molecular biology and evolution, 2018-06, Vol.35 (6), p.1338-1347 [Periódico revisado por pares]

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Título:
Neutral Theory, Microbial Practice: Challenges in Bacterial Population Genetics
Autor: Rocha, Eduardo P C
Kumar, Sudhir
Assuntos: Bacteriology ; Biochemistry, Molecular Biology ; Biodiversity ; Bioinformatics ; Computer Science ; Genetics ; Genomics ; Life Sciences ; Microbiology and Parasitology ; Populations and Evolution ; Quantitative Methods
É parte de: Molecular biology and evolution, 2018-06, Vol.35 (6), p.1338-1347
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: I detail four major open problems in microbial population genetics with direct implications to the study of molecular evolution: the lack of neutral polymorphism, the modeling of promiscuous genetic exchanges, the genetics of ill-defined populations, and the difficulty of untangling selection and demography in the light of these issues. Together with the historical focus on the study of single nucleotide polymorphism and widespread non-random sampling, these problems limit our understanding of the genetic variation in bacterial populations and their adaptive effects. I argue that we need novel theoretical approaches accounting for pervasive selection and strong genetic linkage to better understand microbial evolution.
Editor: United States: Oxford University Press (OUP)
Idioma: Inglês

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