Idioma:

Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast

Marchiò, C ; Iravani, M ; Natrajan, R ; Lambros, MB ; Savage, K ; Tamber, N ; Fenwick, K ; Mackay, A ; Senetta, R ; Palma, S. Di ; Schmitt, FC ; Bussolati, G ; Ellis, IO ; Ashworth, A ; Sapino, A ; Reis-Filho, JS

The Journal of pathology, 2008-08, Vol.215 (4), p.398-410 [Periódico revisado por pares]

Chichester, UK: John Wiley & Sons, Ltd

Texto completo disponível

Citações Citado por

Enviar para

Título:
Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast
Autor: Marchiò, C ; Iravani, M ; Natrajan, R ; Lambros, MB ; Savage, K ; Tamber, N ; Fenwick, K ; Mackay, A ; Senetta, R ; Palma, S. Di ; Schmitt, FC ; Bussolati, G ; Ellis, IO ; Ashworth, A ; Sapino, A ; Reis-Filho, JS
Assuntos: amplification ; Biological and medical sciences ; breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - immunology ; Carcinoma, Ductal, Breast - genetics ; Carcinoma, Ductal, Breast - immunology ; chromogenic in situ hybridization ; comparative genomic hybridization ; Cyclin D1 - genetics ; Disease Progression ; Female ; Gene Amplification ; Gene Expression Profiling - methods ; Genetic Markers ; Gynecology. Andrology. Obstetrics ; histological type ; Humans ; Immunohistochemistry ; Immunophenotyping ; In Situ Hybridization, Fluorescence ; Investigative techniques, diagnostic techniques (general aspects) ; Mammary gland diseases ; Medical sciences ; Oligonucleotide Array Sequence Analysis ; oncogene ; Oncogenes ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Tumors
É parte de: The Journal of pathology, 2008-08, Vol.215 (4), p.398-410
Notas: http://dx.doi.org/10.1002/path.2368
istex:D3CF294BEA5A1EAF4C933A9157543C0CF52A71E7
ArticleID:PATH2368
No conflicts of interest were declared.
ark:/67375/WNG-G4DDC0XH-1
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Pure invasive micropapillary carcinoma (MPC) is a special histological type that accounts for 0.7-3% of all breast cancers. MPC has a distinctive growth pattern and a more aggressive clinical behaviour than invasive ductal carcinomas of no special type (IDC-NSTs). To define the molecular characteristics of MPCs, we profiled a series of 12 MPCs and 24 grade and oestrogen receptor (ER)-matched IDC-NSTs using high-resolution microarray comparative genomic hybridization (aCGH). In addition, we generated a tissue microarray containing a series of 24 MPCs and performed immunohistochemical analysis with ER, PR, Ki-67, HER2, CK5/6, CK14, CK17, EGFR, topoisomerase-IIα, cyclin D1, caveolin-1, E-cadherin, and β-catenin antibodies. In situ hybridization probes were employed to evaluate the prevalence of amplification of HER2, TOP2A, EGFR, CCND1, MYC, ESR1, and FGFR1 genes. aCGH analysis demonstrated that MPCs significantly differed from IDC-NSTs at the genomic level. Gains of 1q, 2q, 4p, 6p, 6q23.2-q27, 7p, 7q, 8p, 8q, 9p, 10p, 11q, 12p, 12q, 16p, 17p, 17q, 19p, 20p, 20q, and 21q, and losses of 1p, 2p, 6q11.1-q16.3, 6q21-q22.1, 9p, 11p, 15q, and 19q were more prevalent in MPCs. High-level gains/amplifications of 8p12-p11, 8q12, 8q13, 8q21, 8q23, 8q24, 17q21, 17q23, and 20q13 were significantly associated with MPCs. A comparison between 24 MPCs and a series of 48 grade and ER-matched IDC-NSTs revealed that high cyclin D1 expression, high proliferation rates, and MYC (8q24) amplification were significantly associated with MPCs. Our results demonstrate that MPCs have distinct histological features and molecular genetic profiles supporting the contention that they constitute a distinct pathological entity. Copyright © 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Editor: Chichester, UK: John Wiley & Sons, Ltd
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast

Marchiò, C ; Iravani, M ; Natrajan, R ; Lambros, MB ; Savage, K ; Tamber, N ; Fenwick, K ; Mackay, A ; Senetta, R ; Palma, S. Di ; Schmitt, FC ; Bussolati, G ; Ellis, IO ; Ashworth, A ; Sapino, A ; Reis-Filho, JS

Chichester, UK: John Wiley & Sons, Ltd

Buscando em bases de dados remotas. Favor aguardar.