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Are Ambient Ultrafine, Accumulation Mode, and Fine Particles Associated with Adverse Cardiac Responses in Patients Undergoing Cardiac Rehabilitation?

Rich, David Q. ; Zareba, Wojciech ; Beckett, William ; Hopke, Philip K. ; Oakes, David ; Frampton, Mark W. ; Bisognano, John ; Chalupa, David ; Bausch, Jan ; O'Shea, Karen ; Wang, Yungang ; Utell, Mark J.

Environmental health perspectives, 2012-08, Vol.120 (8), p.1162-1169 [Periódico revisado por pares]

Research Triangle Park, NC: National Institute of Environmental Health Sciences

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Título:
Are Ambient Ultrafine, Accumulation Mode, and Fine Particles Associated with Adverse Cardiac Responses in Patients Undergoing Cardiac Rehabilitation?
Autor: Rich, David Q. ; Zareba, Wojciech ; Beckett, William ; Hopke, Philip K. ; Oakes, David ; Frampton, Mark W. ; Bisognano, John ; Chalupa, David ; Bausch, Jan ; O'Shea, Karen ; Wang, Yungang ; Utell, Mark J.
Assuntos: Aged ; Aged, 80 and over ; Air ; Air pollution ; Biological and medical sciences ; Blood pressure ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Coronary artery disease ; Environment. Living conditions ; Environmental agencies ; Environmental health ; Environmental pollutants toxicology ; Female ; Health aspects ; Heart ; Heart Diseases - rehabilitation ; Heart rate ; Humans ; Inflammation ; Intervals ; Lag time ; Male ; Medical sciences ; Middle Aged ; Neural networks ; Particle Size ; Particles ; Particulate matter ; Patients ; Pollutants ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Rehabilitation ; Systolic blood pressure ; Toxicology ; White blood cells
É parte de: Environmental health perspectives, 2012-08, Vol.120 (8), p.1162-1169
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Background: Mechanisms underlying previously reported air pollution and cardiovascular (CV) morbidity associations remain poorly understood. Objectives: We examined associations between markers of pathways thought to underlie these air pollution and CV associations and ambient particle concentrations in postinfarction patients. Methods: We studied 76 patients, from June 2006 to November 2009, who participated in a 10-week cardiac rehabilitation program following a recent (within 3 months) myocardial infarction or unstable angina. Ambient ultrafine particle (UFP; 10— 100 nm), accumulation mode particle (AMP; 100— 500 nm), and fine particle concentrations (PM2.5; ≤ 2.5 μm in aerodynamic diameter) were monitored continuously. Continuous Holier electrocardiogram (ECG) recordings were made before and during supervised, graded, twice weekly, exercise sessions. A venous blood sample was collected and blood pressure was measured before sessions. Results: Using mixed effects models, we observed adverse changes in rMSSD [square root of the mean of the sum of the squared differences between adjacent normal-to-normal (NN) intervals], SDNN (standard deviation of all NN beat intervals), TpTe (time from peak to end of T-wave), heart rate turbulence, systolic and diastolic blood pressures, C-reactive protein, and fibrinogen associated with interquartile range increases in UFP, AMP, and PM2.5 at 1 or more lag times within the previous 5 days. Exposures were not associated with MeanNN, heart-rate— corrected QT interval duration (QTc), deceleration capacity, and white blood cell count was not associated with UFP, AMP, and PM2.5 at any lag time. Conclusions: In cardiac rehabilitation patients, particles were associated with subdinical decreases in parasympathetic modulation, prolongation of late repolarization duration, increased blood pressure, and systemic inflammation. It is possible that such changes could increase the risk of CV events in this susceptible population.
Editor: Research Triangle Park, NC: National Institute of Environmental Health Sciences
Idioma: Inglês

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Are Ambient Ultrafine, Accumulation Mode, and Fine Particles Associated with Adverse Cardiac Responses in Patients Undergoing Cardiac Rehabilitation?

Rich, David Q. ; Zareba, Wojciech ; Beckett, William ; Hopke, Philip K. ; Oakes, David ; Frampton, Mark W. ; Bisognano, John ; Chalupa, David ; Bausch, Jan ; O'Shea, Karen ; Wang, Yungang ; Utell, Mark J.

Research Triangle Park, NC: National Institute of Environmental Health Sciences

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