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Mechanisms of Human Innate Immune Evasion by Toxoplasma gondii

Lima, Tatiane S ; Lodoen, Melissa B

Frontiers in cellular and infection microbiology, 2019-04, Vol.9, p.103-103 [Periódico revisado por pares]

Switzerland: Frontiers Media S.A

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  • Título:
    Mechanisms of Human Innate Immune Evasion by Toxoplasma gondii
  • Autor: Lima, Tatiane S ; Lodoen, Melissa B
  • Assuntos: apoptosis ; Cellular and Infection Microbiology ; Host-Pathogen Interactions ; Humans ; IFN-γ ; Immune Evasion ; Immunity, Innate ; innate immunity ; pro-inflammatory cytokines ; Toxoplasma - growth & development ; Toxoplasma - immunology ; Toxoplasma gondii ; Toxoplasmosis - parasitology
  • É parte de: Frontiers in cellular and infection microbiology, 2019-04, Vol.9, p.103-103
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    Reviewed by: Masahiro Yamamoto, Osaka University, Japan; David Allan Christian, University of Pennsylvania, United States
    This article was submitted to Parasite and Host, a section of the journal Frontiers in Cellular and Infection Microbiology
    Edited by: Nicolas Blanchard, INSERM U1043 Centre de Physiopathologie de Toulouse Purpan, France
  • Descrição: is an intracellular protozoan parasite of global importance that can remarkably infect, survive, and replicate in nearly all mammalian cells. Notably, 110 years after its discovery, Toxoplasmosis is still a neglected parasitic infection. Although most human infections with are mild or asymptomatic, infection can result in life-threatening disease in immunocompromised individuals and in the developing fetus due to congenital infection, underscoring the role of the host immune system in controlling the parasite. Recent evidence indicates that elicits a robust innate immune response during infection. Interestingly, however, has evolved strategies to successfully bypass or manipulate the immune system and establish a life-long infection in infected hosts. In particular, manipulates host immunity through the control of host gene transcription and dysregulation of signaling pathways that result in modulation of cell adhesion and migration, secretion of immunoregulatory cytokines, production of microbicidal molecules, and apoptosis. Many of these host-pathogen interactions are governed by parasite effector proteins secreted from the apical secretory organelles, including the rhoptries and dense granules. Here, we review recent findings on mechanisms by which evades host innate immunity, with a focus on parasite evasion of the human innate immune system.
  • Editor: Switzerland: Frontiers Media S.A
  • Idioma: Inglês
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