Idioma:

Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth

Montesano, Roberto

Biochemical and biophysical research communications, 2007-02, Vol.353 (3), p.817-822 [Periódico revisado por pares]

United States: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth
Autor: Montesano, Roberto
Assuntos: Animals ; Anthracenes - pharmacology ; Bone Morphogenetic Protein 4 ; Bone Morphogenetic Proteins - pharmacology ; Butadienes - pharmacology ; Cancer ; Cell adhesion ; Cell Transformation, Neoplastic - pathology ; Cells, Cultured ; Cytokine ; Epithelial Cells - drug effects ; Epithelial Cells - pathology ; Epithelium ; Female ; Humans ; Imidazoles - pharmacology ; Invasion ; Lumen ; Mammary gland ; Mammary Glands, Animal - cytology ; Mice ; Migration ; Mitogen-Activated Protein Kinases - antagonists & inhibitors ; Morphogenesis ; Neoplasm Invasiveness - physiopathology ; Nitriles - pharmacology
É parte de: Biochemical and biophysical research communications, 2007-02, Vol.353 (3), p.817-822
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Bone morphogenetic proteins (BMPs) are multifunctional cytokines that regulate key developmental processes, but are also overexpressed in many carcinomas. To assess whether BMPs would influence the three-dimensional architecture of epithelial structures, we took advantage of an in vitro model in which mammary epithelial cells form alveolar-like spherical cysts in collagen gels. We found that BMP-4 has a dramatic, biphasic effect on the organization of epithelial cysts. When added in the concentration range of 1–10 ng/ml, the cytokine abrogates lumen formation and induces the outgrowth of multiple invasive cord-like structures. At higher concentrations (20–100 ng/ml), BMP-4 additionally disrupts cell–cell adhesion, resulting in cyst disintegration and scattering of individual cells into the surrounding collagen matrix. The finding that BMP-4 subverts the ability of mammary epithelial cells to form polarized lumen-containing structures and endows them with invasive properties supports the involvement of this cytokine in the progression of breast cancer.
Editor: United States: Elsevier Inc
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth

Montesano, Roberto

United States: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.