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Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection

Poston, Taylor B ; Lee, De'Ashia E ; Darville, Toni ; Zhong, Wujuan ; Dong, Li ; O'Connell, Catherine M ; Wiesenfeld, Harold C ; Hillier, Sharon L ; Sempowski, Gregory D ; Zheng, Xiaojing

The Journal of infectious diseases, 2019-06, Vol.220 (2), p.330-339 [Periódico revisado por pares]

United States: Oxford University Press

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Título:
Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection
Autor: Poston, Taylor B ; Lee, De'Ashia E ; Darville, Toni ; Zhong, Wujuan ; Dong, Li ; O'Connell, Catherine M ; Wiesenfeld, Harold C ; Hillier, Sharon L ; Sempowski, Gregory D ; Zheng, Xiaojing
Assuntos: Adolescent ; Adult ; Cervix ; Cervix Uteri - immunology ; Cervix Uteri - microbiology ; Chlamydia ; Chlamydia Infections - immunology ; Chlamydia Infections - microbiology ; Chlamydia trachomatis ; Chlamydia trachomatis - immunology ; CXCL10 protein ; Cytokines ; Cytokines - immunology ; Endometrium ; Female ; Genital tract ; Humans ; Immune response ; Infections ; Interferon ; Interleukin 14 ; Interleukin 16 ; Lymphocytes T ; Major and Brief Reports ; Mucosa ; Mucous Membrane - immunology ; Mucous Membrane - microbiology ; Odds Ratio ; Secretions ; Th17 Cells - immunology ; Th17 Cells - microbiology ; Young Adult
É parte de: The Journal of infectious diseases, 2019-06, Vol.220 (2), p.330-339
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Chlamydia trachomatis can cause reproductive morbidities after ascending to the upper genital tract of women, and repeated infection can lead to worse disease. Data related to protective immune responses at the cervical mucosa that could limit chlamydial infection to the cervix and/or prevent reinfection inform vaccine approaches and biomarkers of risk. We measured 48 cytokines in cervical secretions from women having chlamydial cervical infection alone (n = 92) or both cervical and endometrial infection (n = 68). Univariable regression identified cytokines associated with differential odds of endometrial infection and reinfection risk, and multivariable stepwise regression identified cytokine ratios associated with differential risk. Elevated interleukin (IL) 15/CXCL10 (odds ratio [OR], 0.55 [95% confidence interval {CI}, .37-.78]), IL-16/tumor necrosis factor-α (OR, 0.66 [95% CI, .45-.93]), and CXCL14/IL-17A (OR, 0.73 [95% CI, .54-.97]) cytokine ratios were significantly (P ≤ .05) associated with decreased odds of endometrial infection. A higher Flt-3L/IL-14 ratio was significantly (P = .001) associated with a decreased risk of reinfection (hazard ratio, 0.71 [95% CI, .58-.88]). Cytokines involved in humoral, type I interferon, and T-helper (Th) 17 responses were associated with susceptibility to C. trachomatis, whereas cytokines involved in Th1 polarization, recruitment, and activation were associated with protection against ascension and reinfection.
Editor: United States: Oxford University Press
Idioma: Inglês

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Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection

Poston, Taylor B ; Lee, De'Ashia E ; Darville, Toni ; Zhong, Wujuan ; Dong, Li ; O'Connell, Catherine M ; Wiesenfeld, Harold C ; Hillier, Sharon L ; Sempowski, Gregory D ; Zheng, Xiaojing

United States: Oxford University Press

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