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Hepatitis Delta virus genotype 8 infection in Northeast Brazil: Inheritance from African slaves?

Barros, L.M.F. ; Gomes-Gouvêa, M.S. ; Pinho, J.R.R. ; Alvarado-Mora, M.V. ; Dos Santos, A. ; Mendes-Corrêa, M.C.J. ; Caldas, A.J.M. ; Sousa, M.T. ; Santos, M.D.C. ; Ferreira, A.S.P.

Virus research, 2011-09, Vol.160 (1-2), p.333-339 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Hepatitis Delta virus genotype 8 infection in Northeast Brazil: Inheritance from African slaves?
Autor: Barros, L.M.F. ; Gomes-Gouvêa, M.S. ; Pinho, J.R.R. ; Alvarado-Mora, M.V. ; Dos Santos, A. ; Mendes-Corrêa, M.C.J. ; Caldas, A.J.M. ; Sousa, M.T. ; Santos, M.D.C. ; Ferreira, A.S.P.
Assuntos: Adolescent ; Adult ; Aged ; Aged, 80 and over ; basins ; Bayesian analysis ; Brazil ; Brazil - epidemiology ; Cluster Analysis ; Endemic Diseases ; epidemiological studies ; Female ; Genotype ; HBV ; HDV ; Hepatitis Antibodies - blood ; hepatitis B antigens ; Hepatitis B Surface Antigens - blood ; Hepatitis B virus ; Hepatitis D - epidemiology ; Hepatitis D - virology ; Hepatitis D virus ; Hepatitis Delta virus ; Hepatitis Delta Virus - classification ; Hepatitis Delta Virus - genetics ; Hepatitis Delta Virus - isolation & purification ; Humans ; inheritance (genetics) ; Male ; Middle Aged ; Molecular Sequence Data ; nucleotide sequences ; patients ; people ; Phylogeny ; population ; Prevalence ; public health ; RNA ; RNA, Viral - genetics ; RNA, Viral - isolation & purification ; Sequence Analysis, DNA ; Seroepidemiologic Studies ; seroprevalence ; Young Adult
É parte de: Virus research, 2011-09, Vol.160 (1-2), p.333-339
Notas: http://dx.doi.org/10.1016/j.virusres.2011.07.006
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Descrição: [Display omitted] ► HDV infection was found outside of Amazon region in Brazil. ► African genotype (HDV-8) was found in infected cases. ► Probably HDV-8 was introduced in Brazil from Africa during slave trade. ► Clinical and epidemiological studies are need to clarify the presence of HDV in other areas in Brazil. Hepatitis Delta virus (HDV) is endemic worldwide, but its prevalence varies in different geographical areas. While in the Brazilian Amazon, HDV is known to be endemic and to represent a significant public health problem, few studies have assessed its prevalence in other regions in the country. This study evaluated the seroprevalence of HDV among HBsAg chronic carriers from Maranhão state, a region located in the Northeast of Brazil. Among 133 patients, 5 had anti-HD, of whom 3 had HDV RNA. HDV genotypes were characterized by Bayesian phylogenetic analysis of nucleotide sequences from the HDAg coding region. HDV-3 was identified in one patient who lives in Maranhão, but was born in Amazonas state (Western Amazon basin). Phylogenetic analysis shows that this HDV-3 sequence grouped with other HDV-3 sequences isolated in this state, which suggests that the patient probably contracted HDV infection there. Surprisingly, the other two patients were infected with HDV-8, an African genotype. These patients were born and have always lived in Urbano Santos, a rural county of Maranhão state, moreover they had never been to Africa and denied any contact with people from that continent. This is the first description of the HDV-8 in non-native African populations. This genotype may have been introduced to Brazil through the slaves brought to the country from the West Africa regions during the 16–18th centuries. Our results indicate that the need of clinical and epidemiological studies to investigate the presence of this infection in other areas in Brazil.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Hepatitis Delta virus genotype 8 infection in Northeast Brazil: Inheritance from African slaves?

Barros, L.M.F. ; Gomes-Gouvêa, M.S. ; Pinho, J.R.R. ; Alvarado-Mora, M.V. ; Dos Santos, A. ; Mendes-Corrêa, M.C.J. ; Caldas, A.J.M. ; Sousa, M.T. ; Santos, M.D.C. ; Ferreira, A.S.P.

Netherlands: Elsevier B.V

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