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Host-guided migration allows targeted introduction of neurons into the embryonic brain

Brüstle, O ; Maskos, U ; McKay, R D

Neuron (Cambridge, Mass.), 1995-12, Vol.15 (6), p.1275-1285 [Periódico revisado por pares]

United States: Elsevier Limited

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Título:
Host-guided migration allows targeted introduction of neurons into the embryonic brain
Autor: Brüstle, O ; Maskos, U ; McKay, R D
Assuntos: Animals ; Brain ; Brain - cytology ; Brain - embryology ; Brain architecture ; Cell Differentiation ; Cell migration ; Cell Movement ; Central nervous system ; Chimerism ; Cognitive science ; Embryo, Mammalian ; Embryo, Mammalian - cytology ; Embryo, Mammalian - physiology ; Forebrain ; Histology ; Hybridization ; Hypothalamus ; Leukocyte migration ; Mammals ; Mice ; Mice, Inbred C57BL ; Neural stem cells ; Neurogenesis ; Neurons ; Neurons - cytology ; Neurons - physiology ; Neurons - transplantation ; Neurosciences ; Rats ; Rats, Sprague-Dawley ; Stem Cell Transplantation ; Stem Cells ; Stem Cells - cytology ; Stem Cells - physiology ; Telencephalon ; Transplantation ; Transplantation, Heterologous
É parte de: Neuron (Cambridge, Mass.), 1995-12, Vol.15 (6), p.1275-1285
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The stereotyped positions occupied by individual classes of neurons are a fundamental characteristic of CNS cytoarchitecture. To study the regulation of neuronal positioning, we injected genetically labeled neural precursors derived from dorsal and ventral mouse forebrain into the telencephalic vesicles of embryonic rats. Cells from both areas were found to participate in the generation of telencephalic, diencephalic, and mesencephalic brain regions. Donor-derived neurons populated the host brain in distinct patterns and acquired phenotypic features appropriate for their final location. These observations indicate that neuronal migration and differentiation are predominantly regulated by non-cell-autonomous signals. Exploiting this phenomenon, intrauterine transplantation allows generation of controlled chimerism in the mammalian brain.
Editor: United States: Elsevier Limited
Idioma: Inglês

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Host-guided migration allows targeted introduction of neurons into the embryonic brain

Brüstle, O ; Maskos, U ; McKay, R D

United States: Elsevier Limited

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