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Dengue Virus–Specific Antibodies Enhance Brazilian Zika Virus Infection

Castanha, Priscila M. S. ; Nascimento, Eduardo J. M. ; Braga, Cynthia ; Cordeiro, Marli T. ; de Carvalho, Otávio V. ; de Mendonça, Leila R. ; Azevedo, Elisa A. N. ; França, Rafael F. O. ; Dhalia, Rafael ; Marques, Ernesto T. A.

The Journal of infectious diseases, 2017-03, Vol.215 (5), p.781-785 [Periódico revisado por pares]

US: Oxford University Press

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Título:
Dengue Virus–Specific Antibodies Enhance Brazilian Zika Virus Infection
Autor: Castanha, Priscila M. S. ; Nascimento, Eduardo J. M. ; Braga, Cynthia ; Cordeiro, Marli T. ; de Carvalho, Otávio V. ; de Mendonça, Leila R. ; Azevedo, Elisa A. N. ; França, Rafael F. O. ; Dhalia, Rafael ; Marques, Ernesto T. A.
Assuntos: Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Antibody-Dependent Enhancement ; Antiviral Agents - pharmacology ; Brazil ; Brief Report ; Cross Reactions ; Dengue Virus ; Female ; Humans ; K562 Cells ; Pregnancy ; Receptors, IgG - immunology ; VIRUSES ; Zika Virus - pathogenicity ; Zika Virus Infection - blood ; Zika Virus Infection - immunology
É parte de: The Journal of infectious diseases, 2017-03, Vol.215 (5), p.781-785
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
Correspondence: E. T. A. Marques Jr, MD, PhD, Center for Vaccine Research, 3501 5th Ave, 9052 Biomedical Science Tower 3, Pittsburgh, PA 15261 (marques@pitt.edu).
Descrição: Anti-Flavivirus antibodies are highly cross-reactive and may facilitate Zika virus (ZIKV) infection through the antibody-dependent enhancement (ADE) mechanism. We demonstrate that dengue-specific antibodies enhance the infection of a primary Brazilian ZIKV isolate in a FcγRII-expressing K562 cell line. In addition, we demonstrate that serum samples from dengue-immune pregnant women enhanced ZIKV infection. These findings highlight the need for epidemiological studies and animal models to further confirm the role of ADE in the development of congenital and neurological complications associated with ZIKV infections.
Editor: US: Oxford University Press
Idioma: Inglês

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Dengue Virus–Specific Antibodies Enhance Brazilian Zika Virus Infection

Castanha, Priscila M. S. ; Nascimento, Eduardo J. M. ; Braga, Cynthia ; Cordeiro, Marli T. ; de Carvalho, Otávio V. ; de Mendonça, Leila R. ; Azevedo, Elisa A. N. ; França, Rafael F. O. ; Dhalia, Rafael ; Marques, Ernesto T. A.

US: Oxford University Press

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