skip to main content
Idioma:
Primo Search
Clear Search Box
Search in: Busca Geral
Busca Avançada
Busca por Índices

The non-flagellar type III secretion system evolved from the bacterial flagellum and diversified into host-cell adapted systems

Abby, Sophie S ; Rocha, Eduardo P C Achtman, Mark

PLoS genetics, 2012-09, Vol.8 (9), p.e1002983-e1002983 [Periódico revisado por pares]

United States: Public Library of Science

Texto completo disponível

Citações Citado por
  • Título:
    The non-flagellar type III secretion system evolved from the bacterial flagellum and diversified into host-cell adapted systems
  • Autor: Abby, Sophie S ; Rocha, Eduardo P C
  • Achtman, Mark
  • Assuntos: Adaptation, Biological ; Bacteria ; Bacterial Physiological Phenomena - genetics ; Bacteriology ; Biology ; Cell Movement - genetics ; Computational Biology ; Eukaryotes ; Eukaryotic Cells ; Evolution ; Evolution, Molecular ; Flagella (Microbiology) ; Flagella - genetics ; Genes ; Genetic aspects ; Genetic engineering ; Genomes ; Host-Pathogen Interactions - genetics ; Microbial genetics ; Motility ; Phylogenetics ; Phylogeny ; Physiological aspects ; Proteins ; Secretin - genetics ; Secretin - metabolism
  • É parte de: PLoS genetics, 2012-09, Vol.8 (9), p.e1002983-e1002983
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
    Conceived and designed the experiments: SSA EPCR. Performed the experiments: SSA. Analyzed the data: SSA EPCR. Contributed reagents/materials/analysis tools: SSA EPCR. Wrote the paper: SSA EPCR.
    The authors have declared that no competing interests exist.
  • Descrição: Type 3 secretion systems (T3SSs) are essential components of two complex bacterial machineries: the flagellum, which drives cell motility, and the non-flagellar T3SS (NF-T3SS), which delivers effectors into eukaryotic cells. Yet the origin, specialization, and diversification of these machineries remained unclear. We developed computational tools to identify homologous components of the two systems and to discriminate between them. Our analysis of >1,000 genomes identified 921 T3SSs, including 222 NF-T3SSs. Phylogenomic and comparative analyses of these systems argue that the NF-T3SS arose from an exaptation of the flagellum, i.e. the recruitment of part of the flagellum structure for the evolution of the new protein delivery function. This reconstructed chronology of the exaptation process proceeded in at least two steps. An intermediate ancestral form of NF-T3SS, whose descendants still exist in Myxococcales, lacked elements that are essential for motility and included a subset of NF-T3SS features. We argue that this ancestral version was involved in protein translocation. A second major step in the evolution of NF-T3SSs occurred via recruitment of secretins to the NF-T3SS, an event that occurred at least three times from different systems. In rhizobiales, a partial homologous gene replacement of the secretin resulted in two genes of complementary function. Acquisition of a secretin was followed by the rapid adaptation of the resulting NF-T3SSs to multiple, distinct eukaryotic cell envelopes where they became key in parasitic and mutualistic associations between prokaryotes and eukaryotes. Our work elucidates major steps of the evolutionary scenario leading to extant NF-T3SSs. It demonstrates how molecular evolution can convert one complex molecular machine into a second, equally complex machine by successive deletions, innovations, and recruitment from other molecular systems.
  • Editor: United States: Public Library of Science
  • Idioma: Inglês
Links
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.