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Metabolic signaling by lactate in the brain

Barros, L. Felipe

Trends in neurosciences (Regular ed.), 2013-07, Vol.36 (7), p.396-404 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
Metabolic signaling by lactate in the brain
Autor: Barros, L. Felipe
Assuntos: Animals ; astrocyte ; Astrocytes - metabolism ; Brain ; Brain - metabolism ; Energy Metabolism - physiology ; Glucose ; glycolysis ; HCAR1 ; Humans ; Lactic Acid - metabolism ; NBCe1 ; Neurology ; neuron ; Neurons ; Neurons - metabolism ; Neurosciences ; Tissues
É parte de: Trends in neurosciences (Regular ed.), 2013-07, Vol.36 (7), p.396-404
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Highlights • Synaptic activity is accompanied by a transient rise in brain tissue lactate concentration. • The rise in lactate is explained by acute stimulation of glycolysis in astrocytes, mediated by neuronal release of K+ and glutamate. • Lactate serves as metabolic fuel for active neurons. • Lactate diffuses beyond the active zone, helping to recruit metabolic resources from resting areas and modulating higher-order brain functions.
Editor: England: Elsevier Ltd
Idioma: Inglês

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