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Glia in brain energy metabolism: A perspective

Barros, L. Felipe ; Brown, Angus ; Swanson, Raymond A.

Glia, 2018-06, Vol.66 (6), p.1134-1137 [Periódico revisado por pares]

United States: Wiley Subscription Services, Inc

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  • Título:
    Glia in brain energy metabolism: A perspective
  • Autor: Barros, L. Felipe ; Brown, Angus ; Swanson, Raymond A.
  • Assuntos: Animals ; axon ; Biological evolution ; Brain ; Brain - metabolism ; Brain injury ; Energy Metabolism ; glucose ; glutamate ; glycogen ; Head injuries ; Humans ; In vivo methods and tests ; Injury prevention ; lactate ; Metabolism ; Microglia ; Neural networks ; Neuroglia - metabolism ; Neuronal-glial interactions ; Neurons - metabolism ; nitric oxide ; superoxide ; Temporal resolution
  • É parte de: Glia, 2018-06, Vol.66 (6), p.1134-1137
  • Notas: Funding information
    National Institute of Neurological Disorders and Stroke, Grant Number: RO1 NS081149; Department of Veterans Affairs
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  • Descrição: Early views of glia as relatively inert, housekeeping cells have evolved, and glia are now recognized as dynamic cells that not only respond to neuronal activity but also sense metabolic changes and regulate neuronal metabolism. This evolution has been aided in part by technical advances permitting progressively better spatial and temporal resolution. Recent advances in cell‐type specific genetic manipulation and sub‐cellular metabolic probes promise to further this evolution by enabling study of metabolic interactions between intertwined fine neuronal and glial processes in vivo. Views of glia in disease processes have also evolved. Long considered purely reactive, glia and particularly microglia are now seen to play active roles in both promoting and limiting brain injury. At the same time, established concepts of glial energetics are now being linked to areas such as learning and neural network function, topics previously considered far removed from glial biology. Main Points Prevailing views of glial energetics have been repeatedly revised. Glia are now recognized to both support and influence neuronal energy metabolism. Recent advances highlight influences of glial energetics on cognitive function and disease processes.
  • Editor: United States: Wiley Subscription Services, Inc
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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