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Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis

Navarese, Eliano Pio ; Kolodziejczak, Michalina ; Schulze, Volker ; Gurbel, Paul A ; Tantry, Udaya ; Lin, Yingfeng ; Brockmeyer, Maximilian ; Kandzari, David E ; Kubica, Julia M ; D'Agostino, Sr, Ralph B ; Kubica, Jacek ; Volpe, Massimo ; Agewall, Stefan ; Kereiakes, Dean J ; Kelm, Malte

Annals of internal medicine, 2015-07, Vol.163 (1), p.40-51 [Periódico revisado por pares]

United States: American College of Physicians

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Título:
Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis
Autor: Navarese, Eliano Pio ; Kolodziejczak, Michalina ; Schulze, Volker ; Gurbel, Paul A ; Tantry, Udaya ; Lin, Yingfeng ; Brockmeyer, Maximilian ; Kandzari, David E ; Kubica, Julia M ; D'Agostino, Sr, Ralph B ; Kubica, Jacek ; Volpe, Massimo ; Agewall, Stefan ; Kereiakes, Dean J ; Kelm, Malte
Assuntos: Adults ; Angina, Unstable - prevention & control ; Antibodies, Monoclonal - adverse effects ; Antibodies, Monoclonal - therapeutic use ; Anticholesteremic Agents - adverse effects ; Anticholesteremic Agents - therapeutic use ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - prevention & control ; Cause of Death ; Cholesterol - blood ; Clinical outcomes ; Creatine Kinase - blood ; Female ; Humans ; Hypercholesterolemia - blood ; Hypercholesterolemia - drug therapy ; Lipids ; Lipoprotein(a) - blood ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Monoclonal antibodies ; Myocardial Infarction - prevention & control ; Patient safety ; Proprotein Convertase 9 ; Proprotein Convertases - immunology ; Proteins ; Serine Endopeptidases - immunology
É parte de: Annals of internal medicine, 2015-07, Vol.163 (1), p.40-51
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-4
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Descrição: Guidelines recommend statins as first-line therapy for dyslipidemia. Monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) is a new lipid-lowering approach. To assess the efficacy and safety of PCSK9 antibodies in adults with hypercholesterolemia. MEDLINE, PubMed Central, and Google Scholar; conference proceedings; and the ClinicalTrials.gov registry through 4 April 2015. Phase 2 or 3 randomized, controlled trials (RCTs) comparing treatment using PCSK9 antibodies with no anti-PCSK9 therapy in adults with hypercholesterolemia. Two investigators independently extracted data on study characteristics and lipid and clinical outcomes, and rated risk of bias of trials. Prespecified primary end points were all-cause and cardiovascular mortality. Twenty-four RCTs comprising 10 159 patients were included. Compared with no antibody, treatment with PCSK9 antibodies led to marked reductions in low-density lipoprotein cholesterol levels (mean difference, -47.49% [95% CI, -69.64% to -25.35%]; P < 0.001] and other atherogenic lipid fractions, and it reduced all-cause mortality (odds ratio [OR], 0.45 [CI, 0.23 to 0.86]; P = 0.015; heterogeneity P = 0.63; I2 = 0%) and cardiovascular mortality (OR, 0.50 [CI, 0.23 to 1.10]; P = 0.084; heterogeneity P = 0.78; I2 = 0%). The rate of myocardial infarction was significantly reduced with use of PCSK9 antibodies (OR, 0.49 [CI, 0.26 to 0.93]; P = 0.030; heterogeneity P = 0.45; I2 = 0%), and increases in the serum creatine kinase level were reduced (OR, 0.72 [CI, 0.54 to 0.96]; P = 0.026; heterogeneity P = 0.65; I2 = 0%). Serious adverse events did not increase with administration of PCSK9 antibodies. Results were derived from study-level data rather than patient-level data, and clinical outcome data are rare. PCSK9 antibodies seem to be safe and effective for adults with dyslipidemia. CRC 1116 Masterswitches in Myocardial Ischemia, German Research Council DFG.
Editor: United States: American College of Physicians
Idioma: Inglês

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Effects of Proprotein Convertase Subtilisin/Kexin Type 9 Antibodies in Adults With Hypercholesterolemia: A Systematic Review and Meta-analysis

Navarese, Eliano Pio ; Kolodziejczak, Michalina ; Schulze, Volker ; Gurbel, Paul A ; Tantry, Udaya ; Lin, Yingfeng ; Brockmeyer, Maximilian ; Kandzari, David E ; Kubica, Julia M ; D'Agostino, Sr, Ralph B ; Kubica, Jacek ; Volpe, Massimo ; Agewall, Stefan ; Kereiakes, Dean J ; Kelm, Malte

United States: American College of Physicians

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