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Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route

CARRILHO, F. J ; QUEIROZ, M. L ; DA SILVA, L. C ; PINTO DA FONSECA, L. E ; GRANATO, C ; OBA, I ; OBARA, L

Revista do Instituto de Medicina Tropical de São Paulo, 1989-04, Vol.31 (2), p.91-94 [Periódico revisado por pares]

São Paulo: Instituto de Medicina Tropical de São Paulo

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Título:
Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route
Autor: CARRILHO, F. J ; QUEIROZ, M. L ; DA SILVA, L. C ; PINTO DA FONSECA, L. E ; GRANATO, C ; OBA, I ; OBARA, L
Assuntos: Adult ; Biological and medical sciences ; Female ; Health Workforce ; Hepatitis B ; Hepatitis B - prevention & control ; Hepatitis B Antibodies - analysis ; Hepatitis B Surface Antigens - analysis ; Hepatitis B vaccine ; Hepatitis B virus ; Human viral diseases ; Humans ; Immunization ; Infectious diseases ; Injections, Intradermal ; Male ; Medical sciences ; Middle Aged ; TROPICAL MEDICINE ; Vaccination ; Viral diseases ; Viral hepatitis ; Viral Hepatitis Vaccines - administration & dosage
É parte de: Revista do Instituto de Medicina Tropical de São Paulo, 1989-04, Vol.31 (2), p.91-94
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Schedule for vaccination against HBV infection has usually been based on three separate injections of 20 mcg of the vaccine by intramuscular route. One of the main shortcomings to its use in large scale programs has been its high cost. Ninety out of 300 health workers were submitted to three injections of 2 mcg of plasma-derived vaccine (PDV) by intradermal (ID) route on days 0, 30, and 180. Anti-HBs was detected in 74 (82.2%) after the second dose and in 80 (88.9%) after the third dose, a non-significant difference. However, levels above 10 times the cut-off were observed in 29 (32.2%) and 77 (85.5%), respectively (p less than 0.001). The results showed that a low-dose schedule is effective when used in health workers and should be tried with other risk groups.
Editor: São Paulo: Instituto de Medicina Tropical de São Paulo
Idioma: Inglês;Português

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Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route

CARRILHO, F. J ; QUEIROZ, M. L ; DA SILVA, L. C ; PINTO DA FONSECA, L. E ; GRANATO, C ; OBA, I ; OBARA, L

São Paulo: Instituto de Medicina Tropical de São Paulo

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