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Detection and molecular characterization of the novel recombinant norovirus GII.P16-GII.4 Sydney in southeastern Brazil in 2016

Barreira, Débora Maria Pires Gonçalves ; Fumian, Túlio Machado ; Tonini, Marco André Loureiro ; Volpini, Lays Paula Bondi ; Santos, Rodrigo Pratte ; Ribeiro, Anézia Lima Chaves ; Leite, José Paulo Gagliardi ; Souza, Márcia Terezinha Baroni de Moraes E ; Brasil, Patrícia ; da Cunha, Denise Cotrim ; Miagostovich, Marize Pereira ; Spano, Liliana Cruz Roques, Pierre

PloS one, 2017-12, Vol.12 (12), p.e0189504-e0189504 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Detection and molecular characterization of the novel recombinant norovirus GII.P16-GII.4 Sydney in southeastern Brazil in 2016
Autor: Barreira, Débora Maria Pires Gonçalves ; Fumian, Túlio Machado ; Tonini, Marco André Loureiro ; Volpini, Lays Paula Bondi ; Santos, Rodrigo Pratte ; Ribeiro, Anézia Lima Chaves ; Leite, José Paulo Gagliardi ; Souza, Márcia Terezinha Baroni de Moraes E ; Brasil, Patrícia ; da Cunha, Denise Cotrim ; Miagostovich, Marize Pereira ; Spano, Liliana Cruz
Roques, Pierre
Assuntos: Age ; Biology and life sciences ; Causes of ; Children ; Children's hospitals ; Computer and Information Sciences ; Epidemics ; Epidemiology ; Gastroenteritis ; Genetic aspects ; Genetic diversity ; Genomes ; Genotype & phenotype ; Health care facilities ; Hospital facilities ; Laboratories ; Medicine and Health Sciences ; Norovirus ; Outbreaks ; Pandemics ; Pathology ; People and places ; Proteins ; Public health ; Research and analysis methods ; RNA polymerase ; Sentinel surveillance ; Surveillance ; Virology ; Viruses
É parte de: PloS one, 2017-12, Vol.12 (12), p.e0189504-e0189504
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
Competing Interests: The authors have declared that no competing interests exist.
Descrição: Noroviruses are the leading cause of acute gastroenteritis (AGE) in all age groups worldwide. Despite the high genetic diversity of noroviruses, most AGE outbreaks are caused by a single norovirus genotype: GII.4. Since 1995, several different variants of norovirus GII.4 have been associated with pandemics, with each variant circulating for 3 to 8 years. The Sydney_2012 variant was first reported in Australia and then in other countries. A new variant, GII.P16-GII.4, was recently described in Japan and South Korea and then in the USA, France, Germany and England. In our study, 190 faecal specimens were collected from children admitted to a paediatric hospital and a public health facility during a surveillance study of sporadic cases of AGE conducted between January 2015 and July 2016. The norovirus was detected by RT-qPCR in 51 samples (26.8%), and in 37 of them (72.5%), the ORF1-2 junction was successfully sequenced. The new recombinant GII.P16-GII.4 Sydney was revealed for the first time in Brazil in 2016 and predominated among other strains (9 GII.Pe-GII.4, 3 GII.P17-GII.17, 1 GII.Pg-GII.1, 1 GII.P16-GII.3 and 1 GII.PNA-GII.4). The epidemiological significance of this new recombinant is still unknown, but continuous surveillance studies may evaluate its impact on the population, its potential to replace the first recombinant GII.Pe-GII.4 Sydney 2012 variant, and the emergence of new recombinant forms of GII.P16.
Editor: United States: Public Library of Science
Idioma: Inglês

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Detection and molecular characterization of the novel recombinant norovirus GII.P16-GII.4 Sydney in southeastern Brazil in 2016

United States: Public Library of Science

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