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Cardiorespiratory effects induced by acetazolamide on the ventromedullary surface of the cat

Andreatta‐van Leyen, S ; Averill, D B ; Guertzenstein, P G

The Journal of physiology, 1990-02, Vol.421 (1), p.171-184 [Periódico revisado por pares]

Oxford: The Physiological Society

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Título:
Cardiorespiratory effects induced by acetazolamide on the ventromedullary surface of the cat
Autor: Andreatta‐van Leyen, S ; Averill, D B ; Guertzenstein, P G
Assuntos: Acetazolamide - pharmacology ; Animals ; Aorta - innervation ; Biological and medical sciences ; Blood Pressure - drug effects ; Carbon Dioxide - physiology ; Cardiorespiratory control. Arterial mecano- and chemoreceptor ; Carotid Sinus - physiology ; Cats ; Chemoreceptor Cells - physiology ; Female ; Fundamental and applied biological sciences. Psychology ; Heart Rate - drug effects ; Male ; Medulla Oblongata - drug effects ; Phrenic Nerve - physiology ; Pressoreceptors - physiology ; Respiration - drug effects ; Vagotomy ; Vertebrates: respiratory system
É parte de: The Journal of physiology, 1990-02, Vol.421 (1), p.171-184
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: 1. Inhibition of carbonic anhydrase by acetazolamide in alpha-chloralose-anaesthetized cats, in a region of the brain stem co-extensive with the glycine-sensitive area, intermediate chemosensitive area, and probably C1 catecholaminergic neurones produces hypotension, bradycardia and depression of the central respiratory drive. 2. These responses are concentration dependent, and can still be observed when the enzyme substrate (CO2) is elevated. Therefore, in both the hypercapnic and the normocapnic condition, similar responses in arterial blood pressure, heart rate and respiratory rate are observed when acetazolamide is topically applied to the glycine-sensitive area. 3. To investigate further the contribution of peripheral baro-, chemo- and cardiopulmonary receptors to these responses, acetazolamide was topically applied to the glycine-sensitive area under three different conditions: intact gallamine-paralysed (5 mg kg-1 h-1) and artificially ventilated (A), sinoaortic denervated (B), and sinoaortic denervated plus bilaterally vagotomized cats (C). Under all conditions, similar responses were observed. The fall in arterial blood pressure was 75 +/- 11 (A), 90 +/- 13 (B), and 75 +/- 9 mmHg (C). Changes in heart rate during acetazolamide application were -23 +/- 6, -20 +/- 8, and -26 +/- 6 beats min-1, respectively. The decreases in respiratory rate were 9 +/- 2 (A), 11 +/- 2 (B), and 11 +/- 2 breaths min-1 (C). 4. The data indicate that the responses to topical application of acetazolamide are mainly due to its central action at the glycine-sensitive area and are not influenced by peripheral baroreceptor and chemoreceptor inputs.
Editor: Oxford: The Physiological Society
Idioma: Inglês

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Cardiorespiratory effects induced by acetazolamide on the ventromedullary surface of the cat

Andreatta‐van Leyen, S ; Averill, D B ; Guertzenstein, P G

Oxford: The Physiological Society

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