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The Randomized Registry Trial — The Next Disruptive Technology in Clinical Research?

Lauer, Michael S ; D'Agostino, Ralph B

The New England journal of medicine, 2013-10, Vol.369 (17), p.1579-1581 [Periódico revisado por pares]

United States: Massachusetts Medical Society

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  • Título:
    The Randomized Registry Trial — The Next Disruptive Technology in Clinical Research?
  • Autor: Lauer, Michael S ; D'Agostino, Ralph B
  • Assuntos: Acute coronary syndromes ; Clinical trials ; Comparative Effectiveness Research ; Design ; Heart attacks ; Humans ; Information management ; R&D ; Randomized Controlled Trials as Topic ; Registries ; Research & development ; Roosevelt, Theodore (1858-1919) ; Technology application
  • É parte de: The New England journal of medicine, 2013-10, Vol.369 (17), p.1579-1581
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
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  • Descrição: The registry-based randomized trial may make less expensive, more efficient clinical studies possible. But before the new study design can be widely used, questions about the quality of the underlying data sets must be addressed. The randomized trial is one of the most powerful tools clinical researchers possess, a tool that enables them to evaluate the effectiveness of new (or established) therapies while accounting for the effects of unmeasured confounders and selection bias by indication. Randomized trials, especially huge megatrials, have transformed medical practice. Thanks to randomized trials, we no longer, for example, treat acute myocardial infarction with lidocaine and nitrates. Instead we use rapid revascularization, anticoagulants, and antiplatelet agents, and during long-term follow-up we routinely prescribe statins, beta-blockers, and angiotensin-converting–enzyme inhibitors. But the reputation of randomized trials has suffered of late, 1 owing to reasonable . . .
  • Editor: United States: Massachusetts Medical Society
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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