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Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

Fintelman-Rodrigues, Natalia ; da Silva, Aline P D ; Dos Santos, Monique Cristina ; Saraiva, Felipe B ; Ferreira, Marcelo A ; Gesto, João ; Rodrigues, Danielle A S ; Vale, André M ; de Azevedo, Isaclaudia G ; Soares, Vinícius C ; Jiang, Hui ; Tan, Hongdong ; Tschoeke, Diogo A ; Sacramento, Carolina Q ; Bozza, Fernando A ; Morel, Carlos M ; Bozza, Patrícia T ; Souza, Thiago Moreno L

Emerging infectious diseases, 2021-05, Vol.27 (5), p.1446-1453 [Periódico revisado por pares]

United States: U.S. National Center for Infectious Diseases

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Título:
Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil
Autor: Fintelman-Rodrigues, Natalia ; da Silva, Aline P D ; Dos Santos, Monique Cristina ; Saraiva, Felipe B ; Ferreira, Marcelo A ; Gesto, João ; Rodrigues, Danielle A S ; Vale, André M ; de Azevedo, Isaclaudia G ; Soares, Vinícius C ; Jiang, Hui ; Tan, Hongdong ; Tschoeke, Diogo A ; Sacramento, Carolina Q ; Bozza, Fernando A ; Morel, Carlos M ; Bozza, Patrícia T ; Souza, Thiago Moreno L
Assuntos: Chemokines ; coronavirus disease ; Coronaviruses ; COVID-19 ; Cytokines ; Disease transmission ; Diseases ; Genetic aspects ; Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil ; Genomes ; Health aspects ; Households ; Immune response ; Infections ; Medical research ; Pandemics ; Patients ; Relapse ; respiratory infections ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Task forces ; viruses
É parte de: Emerging infectious diseases, 2021-05, Vol.27 (5), p.1446-1453
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.
Editor: United States: U.S. National Center for Infectious Diseases
Idioma: Inglês

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Genetic Evidence and Host Immune Response in Persons Reinfected with SARS-CoV-2, Brazil

United States: U.S. National Center for Infectious Diseases

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