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The Interplay between the Bone and the Immune System

Mori, Giorgio ; D'Amelio, Patrizia ; Faccio, Roberta ; Brunetti, Giacomina Maggi, Enrico

Clinical & developmental immunology, 2013-01, Vol.2013, p.720504-16 [Periódico revisado por pares]

Egypt: Hindawi Publishing Corporation

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Título:
The Interplay between the Bone and the Immune System
Autor: Mori, Giorgio ; D'Amelio, Patrizia ; Faccio, Roberta ; Brunetti, Giacomina
Maggi, Enrico
Assuntos: Adapter proteins ; Animals ; Bone and Bones - immunology ; Bone diseases ; Bone marrow ; Bone Resorption - immunology ; Colleges & universities ; Cytokines ; Homeostasis ; Humans ; Immune system ; Immune System - physiology ; Kinases ; Ligands ; Osteoblasts - physiology ; Osteoclasts - physiology ; Osteocytes - physiology ; Osteogenesis - physiology ; Review
É parte de: Clinical & developmental immunology, 2013-01, Vol.2013, p.720504-16
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
ObjectType-Review-1
Academic Editor: Enrico Maggi
Descrição: In the last two decades, numerous scientists have highlighted the interactions between bone and immune cells as well as their overlapping regulatory mechanisms. For example, osteoclasts, the bone-resorbing cells, are derived from the same myeloid precursor cells that give rise to macrophages and myeloid dendritic cells. On the other hand, osteoblasts, the bone-forming cells, regulate hematopoietic stem cell niches from which all blood and immune cells are derived. Furthermore, many of the soluble mediators of immune cells, including cytokines and growth factors, regulate the activities of osteoblasts and osteoclasts. This increased recognition of the complex interactions between the immune system and bone led to the development of the interdisciplinary osteoimmunology field. Research in this field has great potential to provide a better understanding of the pathogenesis of several diseases affecting both the bone and immune systems, thus providing the molecular basis for novel therapeutic strategies. In these review, we reported the latest findings about the reciprocal regulation of bone and immune cells.
Editor: Egypt: Hindawi Publishing Corporation
Idioma: Inglês

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The Interplay between the Bone and the Immune System

Mori, Giorgio ; D'Amelio, Patrizia ; Faccio, Roberta ; Brunetti, Giacomina Maggi, Enrico

Egypt: Hindawi Publishing Corporation

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