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The anti-leukemic efficacy of the third generation bisphosphonate ONO5920/YM529

Segawa, Hidekazu ; Kimura, Shinya ; Kuroda, Junya ; Sato, Kiyoshi ; Nogawa, Masaki ; Yuasa, Takeshi ; Yokota, Asumi ; Hodohara, Keiko ; Fujiyama, Yoshihide ; Maekawa, Taira

Leukemia research, 2005-04, Vol.29 (4), p.451-457 [Periódico revisado por pares]

England: Elsevier Ltd

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Título:
The anti-leukemic efficacy of the third generation bisphosphonate ONO5920/YM529
Autor: Segawa, Hidekazu ; Kimura, Shinya ; Kuroda, Junya ; Sato, Kiyoshi ; Nogawa, Masaki ; Yuasa, Takeshi ; Yokota, Asumi ; Hodohara, Keiko ; Fujiyama, Yoshihide ; Maekawa, Taira
Assuntos: Animals ; Antineoplastic Agents - toxicity ; Apoptosis ; Bisphosphonate ; Cell Division - drug effects ; Cell Line, Tumor ; Diphosphonates - toxicity ; HL-60 Cells ; Humans ; Imidazoles - toxicity ; K562 Cells ; Leukemia ; Leukemia - drug therapy ; Mice ; Mice, SCID ; Protein Prenylation - drug effects ; Ras proteins ; ras Proteins - drug effects ; ras Proteins - metabolism ; Transplantation, Heterologous ; YM529
É parte de: Leukemia research, 2005-04, Vol.29 (4), p.451-457
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Descrição: Ras proteins are frequently over-expressed in leukemia and contribute to leukemogenesis. We evaluated the anti-leukemic efficacy of a new third-generation bisphosphonate, ONO5920/YM529 (YM529). YM529 prevents the prenylation of Ras proteins and inhibited the growth of leukemic cells including a P-glycoprotein (P-gp) over-expressing cell line in a concentration- and time-dependent manner by inducing apoptosis in vitro. Moreover, YM529 synergistically augmented the anti-leukemic activities of paclitaxel and daunorubicin in vitro. Importantly, YM529 prolonged the survival of NOD/SCID mice engrafted with human primary leukemic cells. These findings indicate that the YM529 may become a novel molecular therapeutic class for treatment of leukemias.
Editor: England: Elsevier Ltd
Idioma: Inglês

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The anti-leukemic efficacy of the third generation bisphosphonate ONO5920/YM529

Segawa, Hidekazu ; Kimura, Shinya ; Kuroda, Junya ; Sato, Kiyoshi ; Nogawa, Masaki ; Yuasa, Takeshi ; Yokota, Asumi ; Hodohara, Keiko ; Fujiyama, Yoshihide ; Maekawa, Taira

England: Elsevier Ltd

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