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Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells

Jia, Yannan ; Ji, Liu ; Zhang, Shuai ; Xu, Lina ; Yin, Lianhong ; Li, Lei ; Zhao, Yanyan ; Peng, Jinyong

Food and chemical toxicology, 2012-09, Vol.50 (9), p.3133-3141 [Periódico revisado por pares]

Oxford: Elsevier Ltd

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Título:
Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells
Autor: Jia, Yannan ; Ji, Liu ; Zhang, Shuai ; Xu, Lina ; Yin, Lianhong ; Li, Lei ; Zhao, Yanyan ; Peng, Jinyong
Assuntos: Biological and medical sciences ; Blotting, Western ; caspase-3 ; Cells, Cultured ; cerebrovascular disorders ; DNA ; Endothelium, Vascular - cytology ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - metabolism ; flavonoids ; Flavonoids - pharmacology ; Flow Cytometry ; glutathione ; Glutathione - metabolism ; H2O2-induced damage ; Human umbilical vein endothelial cells ; Humans ; hydrogen peroxide ; Hydrogen Peroxide - antagonists & inhibitors ; Hydrogen Peroxide - toxicity ; In Situ Nick-End Labeling ; interphase ; Medical sciences ; Membrane Potential, Mitochondrial - drug effects ; Microscopy, Electron, Transmission ; mitochondrial membrane ; Nitric Oxide - biosynthesis ; protective effect ; Reactive Oxygen Species - metabolism ; Rosa - chemistry ; Rosa laevigata ; Rosa laevigata Michx ; Total flavonoids ; Toxicology ; Umbilical Veins - cytology ; Umbilical Veins - drug effects ; Umbilical Veins - metabolism
É parte de: Food and chemical toxicology, 2012-09, Vol.50 (9), p.3133-3141
Notas: http://dx.doi.org/10.1016/j.fct.2012.06.047
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Descrição: ► TFs from RLMF could protect HUVECs against H2O2 induced damage. ► TFs could keep the normal morphology of nuclear and mitochondria. ► TFs had antioxidant activity. ► TFs could affect the expressions of some proteins related to mitochondrial pathway. The aim of the present study was to evaluate the protective effect and possible mechanism of the total flavonoids (TFs) from Rosa Laevigata Michx fruit (RLMF) against hydrogen peroxide (H2O2) induced damage in human umbilical vein endothelial cells (HUVECs). The cell injury caused by H2O2 was protected by pretreatment with the TFs for 1h. Compared with the model group, the TFs decreased S phase cells, suppressed nuclear morphological damage, inhibited the collapse of mitochondrial membrane potentials (ΔΨm), attenuated excessive reactive oxygen species generation, reduced glutathione depletion, impacted the mitochondrial morphology change, decreased caspase-3, -9 activities, and decreased fragmented DNA. Further mechanism investigation showed that the TFs could increase the protein expressions of Procaspase-3, Bcl-2, and decrease the expressions of Bak, Bax, Bid and p53. Generally, the TFs from RLMF is an effective natural product for the treatment of cardiovascular and cerebrovascular diseases.
Editor: Oxford: Elsevier Ltd
Idioma: Inglês

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Total flavonoids from Rosa Laevigata Michx fruit attenuates hydrogen peroxide induced injury in human umbilical vein endothelial cells

Jia, Yannan ; Ji, Liu ; Zhang, Shuai ; Xu, Lina ; Yin, Lianhong ; Li, Lei ; Zhao, Yanyan ; Peng, Jinyong

Oxford: Elsevier Ltd

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